Colipase - Wikipedia
Colipase, abbreviated CLPS, is a protein co-enzyme that counteracts the inhibitory effect of intestinal bile acid on the enzymatic activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin.
Colipase: structure and interaction with pancreatic lipase
1999年11月23日 · Colipase is a small protein cofactor needed by pancreatic lipase for the efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilising an active conformation and considerably increasing the …
Colipase - an overview | ScienceDirect Topics
Colipase belongs to a family of small cysteine-rich proteins which lack extensive secondary structure. It is a fairly flat molecule of dimensions 25×30×35 Å. Colipase can be described as an assembly of protruding fingers, held together at one end …
Colipase - an overview | ScienceDirect Topics
Bile-salt activated lipase (EC3.1.1.3) from pancreas in conjunction with colipase is the major digestive enzyme for the hydrolysis of CLA-containing di- and triglycerides. Micelles form spontaneously from the mixture of fatty acids, monoglycerides, bile acids, and phospholipids.
Crystallographic study of the structure of colipase and of ...
Colipase (Mr 10 kDa) confers catalytic activity to pancreatic lipase under physiological conditions (high bile salt concentrations). Previously determined 3-A-resolution X-ray structures of lipase-colipase complexes have shown that, in the absence ...
Structure and function of pancreatic lipase and colipase
This review discusses the advances made in protein structure and in understanding the relationships of structure to function of pancreatic triglyceride lipase and colipase.
Colipase - Wikiwand
Colipase is a small protein cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. Efficient absorption of dietary fats is dependent on the action of pancreatic triglyceride lipase.
Crystallographic study of the structure of colipase and of ...
Covalent inhibition of the pancreatic lipase by a phosphonate inhibitor yields better diffracting crystals of the lipase-colipase complex. From the 2.4-A-resolution structure of this complex, we give an accurate description of the colipase.
Colipase Stabilizes the Lid Domain of Pancreatic Triglyceride ...
Pancreatic lipase is characterized by increased activity against water-insoluble substrates and by dependence on another protein, colipase, for binding to the substrate interface. In most models of pancreatic lipase activity, colipase functions to anchor lipase on the substrate interface.
Combined pancreatic lipase-colipase deficiency | About the ...
Combined pancreatic lipase-colipase deficiency is a disorder of lipid absorption and transport characterized by steatorrhea with foul-smelling stools from birth, diminished serum carotene and vitamin E and a combined deficiency of the pancreatic enzymes lipase and colipase.
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