- Complement-dependent cytotoxicity (CDC) is an immune response in which target cells are lysed through activation and recruitment of the complement cascade to the targeted cell surface12345. The complement system consists of over 20 small proteins synthesized by various tissues and cell types, including immune cells, and is regulated by 3 different pathways3. CDC is initiated when C1q, the initiating component of the classical complement pathway, is fixed to the Fc portion of target-bound antibodies4. CDC is one mechanism of action by which therapeutic antibodies or antibody fragments can achieve an antitumor effect5.了解详细信息：✕以上信息汇总借助人工智能技术，若访问原文请查看了解详细信息。
Complement-dependent cytotoxicity (CDC) is an immune response in which target cells are lysed through activation and recruitment of the complement cascade to the targeted cell surface. The CDC is a tightly regulated...
horizondiscovery.com/en/screening/immunology-se…In complement-dependent cytotoxicity (CDC), C1q binds to antibodies, which triggers the complement cascade, resulting in the formation of a membrane attack complex (MAC) (C5b to C9) on the surface of target cells,...
www.creative-biolabs.com/immuno-oncology/adcc …Complement-dependent cytotoxicity (CDC) is one mechanism by which antibodies can mediate specific target cell lysis through activation of an organism’s complement system. The complement system consists of over 20...
iqbiosciences.com/bioservices/in-vitro_bioservices/…Complement-dependent cytotoxicity/CDC is initiated when C1q, the initiating component of the classical complement pathway, is fixed to the Fc portion of target-bound antibodies. Once C1q binds to the antibody Fc,...
www.sinobiological.com/research/complement-syst…Complement system is efficiently activated by human IgG1, IgG3 and IgM antibodies, weakly by IgG2 antibodies and it is not activated by IgG4 antibodies. It is one mechanism of action by which therapeutic antibodies...
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Complement-dependent cytotoxicity (CDC) is an effector function of IgG and IgM antibodies. When they are bound to surface antigen on target cell (e.g. bacterial or viral infected cell), the classical complement pathway is triggered by bonding protein C1q to these antibodies, resulting in formation of a membrane attack … 展开
• Contrast with antibody-dependent cellular cytotoxicity (ADCC) 展开
CC-BY-SA 许可证中的维基百科文本 【干货】抗体介导的ADCC和CDC作用 - 知乎 - 知乎专栏
补体依赖的细胞毒性 作用（complement dependent cytotoxicity, CDC）。 前者是指抗体的Fab段与感染或肿瘤细胞的 抗原表位 结合，Fc段与杀伤细胞（NK细胞、巨噬细胞等）表面的FcR结合，介导杀伤细胞直接杀伤靶细胞的作用。
抗体药物作用机制——补体依赖的细胞毒性作用（CDC效应） - 知乎
其中Fab端可通过识别游离的分子（如VEGF）和细胞表面分子（如CD20，CD19）执行其功能）；而Fc端则决定了抗体的效应功能，比如今天所要介绍的补体依赖性细胞毒性作 …
Complement Dependent Cytotoxicity - an overview | ScienceDirect …
32 行 · Complement-dependent cytotoxicity (CDC) is a key mechanism undergirding the use of therapeutic antibodies employed in the treatment of cancer and autoimmune diseases …
补体依赖的细胞毒性 - 百度百科
补体依赖的细胞毒性（complement dependent cytotoxicity;CDC ），指的是补体参与的细胞毒作用，即通过特异性抗体与细胞膜表面相应抗原结合，形成复合物而激活补体经典途径，所形成的 …
Complement Dependent Cytotoxicity - an overview | ScienceDirect …
Complement-dependent cytotoxicity (CDC) is an effector mechanism of IgG and IgM Abs. These opsonized Abs bind to a target cell in the presence of the C1q protein in the classical …
Regulation of antibody-mediated complement-dependent …
Complement-dependent cytotoxicity (CDC) is a potent effector mechanism, engaging both innate and adaptive immunity. Although strategies to improve the CDC activity of antibody …
抗体Fc端ADCC和CDC功能活性介绍 - 健康界
2023年7月28日 · ADCC（antibody-dependent cell-mediated cytotoxicity）：即抗体依赖的细胞介导的细胞毒作用，当抗体Fab端与靶细胞表面抗原表位结合后，其Fc端招募效应细胞（NK细胞、巨噬细胞）并与其表面Fc受体（FcγR）结合， …
Complement Dependent Cytotoxicity - ScienceDirect Topics
Complement-dependent cytotoxicity (CDC) method is the classic test that involves mixing potential recipient serum with donor T and B lymphocytes in the presence of complement. …
The Role of Complement in the Mechanism of Action of …
Several mAbs also activate the classical complement pathway and promote complement-dependent cytotoxicity (CDC), although with very different levels of efficacy, depending on the …
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