Congenital insensitivity to pain (CIP), also known as congenital analgesia, is one or more extraordinarily rare conditions in which a person cannot feel (and has never felt) physical pain. [1]

2024年6月9日 · Also called congenital analgesia or congenital indifference to pain, congenital pain insensitivity is a kind of peripheral neuropathy — specifically, a type of hereditary sensory and...

2018年2月8日 · Congenital insensitivity to pain (CIP) is an extremely rare phenotype characterized by the inability to perceive pain (absence of nociception) from birth. Individuals with CIP do not feel pain from any noxious stimuli, including inflammation and …

This review aims to explore congenital insensitivity to pain, an extremely rare genetic disorder with an autosomal recessive pattern that results in the inability to perceive pain. We will focus on the well-known subtype, congenital insensitivity to pain with anhidrosis (CIPA).

First described in 1932 by Dearborn as ‘congenital pure analgesia’, congenital insensitivity to pain and anhydrosis (CIPA) or hereditary sensory and autonomic neuropathy (HSAN) type IV is an extremely rare autosomal recessive disorder.

Channelopathy-associated congenital insensitivity to pain is a condition that inhibits the ability to perceive physical pain. From birth, affected individuals never feel pain in any part of their body when injured.

2012年11月1日 · Congenital insensitivity to pain is considered a form of peripheral neuropathy because it affects the peripheral nervous system, which connects the brain and spinal cord to muscles and to cells that detect sensations such as touch, smell, and pain.

Congenital insensitivity to pain (CIP) is an extremely rare human phenotype where no pain of any type is experienced during an affected individuals’ lifetime. For the senses of sight and hearing, more than a hundred Mendelian disorders are each known that cause a …

2023年3月20日 · Congenital insensitivity to pain and anhidrosis (CIPA) is a rare disease that causes a person to not be able to feel pain or sweat. CIPA is also known as hereditary …

Congenital insensitivity to pain is most commonly caused by changes (mutations) in the SCN9A gene. This gene provides instructions for making one part (the alpha subunit) of a sodium channel called NaV1.7. Sodium channels play an important role in making and sending electrical signals.