2021年2月15日 · Direct antiglobulin test (DAT or Coombs test): tests whether patient RBCs are coated with antibodies present in vivo Indirect antiglobulin test (IAT or indirect Coombs test): tests whether antibodies from a patient bind to reagent RBCs in vitro

2021年7月19日 · Positive Coombs test, evidence of extravascular rather than intravascular hemolytic anemia (Oxf Med Case Reports 2020;2020:omz125) Various presentations of microangiopathic and macroangiopathic anemia; Sickle cell disease: Vaso-occlusion and vasculopathy with early onset and chronic progression (Intern Emerg Med 2019;14:1051)

2023年11月28日 · A 55 year old woman with chronic lymphocytic lymphoma (CLL) presented with anemia and reticulocytosis, a negative routine direct antiglobulin test (DAT) for both complement and IgG, a negative red cell antibody screen, elevated lactate dehydrogenase (LDH), severely decreased haptoglobin and indirect hyperbilirubinemia.

2024年3月15日 · Negative Coombs test Reference: Clin J Am Soc Nephrol 2018;13:300. Prognostic factors.

2021年3月12日 · In association with systemic lupus erythematosus: antinuclear antibody titer, anti-dsDNA, Coombs test, complement protein C3, C4, CH50 or immune complex assays (C1q or C3d) May be differentiated from other associated autoimmune disorders by antiphospholipid and anticardiolipin antibodies, rheumatoid factor, anti-Mi2, antitopoisomerase I and ...

Direct antiglobulin (Coombs) test (DAT) is negative. Diagnosis : Thrombocytopenia and microangiopathic hemolytic anemia and a severe ADAMTS13 deficiency (< 10% normal values), in the absence of anti-ADAMTS13 antibodies, suggest a diagnosis of congenital TTP.

2021年6月8日 · Additional tests to exclude other underlying causes of cytopenia(s), as clinically appropriate (i.e. vitamin B12, folate and iron, Coombs test, etc.) Reference: Foucar: Diagnostic Pathology - Blood and Bone Marrow, 2nd Edition, 2017

Blood bank testing: ABO discrepancies adsorption studies antibody identification & panel interpretation automation cold autoantibody testing (pending) Coombs test / DAT DAT negative autoimmune hemolytic anemia enzyme treatment (pending) neutralization and lectins (pending) pretransfusion testing red blood cell genotyping (pending) warm ...

2023年8月8日 · Prevalence is low when indirect antiglobulin test is negative (< 1%) Significant portion of patients with WAA form new RBC alloantibody (~15%); however, the use of prophylactic antigen matched (PAM) approach for RBC selection does not appear to be protective against new alloimmunization (Vox Sang 2020;115:515)

2020年4月2日 · Preferred screening test is Ratio of plasma aldosterone concentration (PAC, in ng/dl) to plasma renin activity (PRA, in ng/ml/hr) Ratio >30 is strongly suggestive of primary hyperaldosteronism. Confirmatory test: Serum aldosterone level, urine aldosterone levels, saline suppression test