Thinking of COVID-19 and its relationship with ACE2, an in-depth understanding of pathogenesis might aid in the progress of targeted interventions so as to regulate this pandemic. The highly complex relationship persists between the RAAS and SARS-CoV pathogenicity, and by analogy, SARS-CoV-2 pathogenicity in the circumstances of COVID-19.

ACE2 is a key regulator of the renin–angiotensin–aldosterone system (RAAS). SARS-CoV-2 causes ACE/ACE2 balance disruption and RAAS activation, which leads ultimately to COVID-19 progression, especially in patients with comorbidities, such as hypertension, diabetes mellitus, and cardiovascular disease.

4 天之前 · It is known that the angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 [].Here, we hypothesize that there may be a link between AD and COVID-19 through the expression of ACE2.

2020年7月13日 · Considering that the spike protein of SARS-CoV-2 interacts with ACE2, as does that of SARS-CoV, COVID-19 may have a pathogenic mechanism similar to that of SARS. In this review, we will discuss the role of ACE2 in COVID-19, and its potential therapeutic targets, aiming to provide more information on the management of the epidemic. RAS and ACE2

ACE2 is a key regulator of the renin-angiotensin-aldosterone system (RAAS). SARS-CoV-2 causes ACE/ACE2 balance disruption and RAAS activation, which leads ultimately to COVID-19 progression, especially in patients with comorbidities, such as hypertension, diabetes mellitus, and cardiovascular disease.

2025年3月14日 · Severe acute respiratory syndrome coronavirus (SARS-CoV) (1–4) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5–9) have crossed the species barrier to infect humans.Both SARS-CoV and SARS-CoV-2 have been identified to use their spike (S) proteins on the virus surface to bind human angiotensin-converting enzyme 2 (hACE2) as the receptor to enter human cells (5, 10).

2021年1月3日 · ACE2 is a key regulator of the renin–angiotensin–aldosterone system (RAAS). SARS-CoV-2 causes ACE/ACE2 balance disruption and RAAS activation, which leads ultimately to COVID-19 progression, especially in patients with comorbidities, such as hypertension, diabetes mellitus, and cardiovascular disease.

2022年3月3日 · Here, through a genome-wide association study, we identify a variant (rs190509934, minor allele frequency 0.2–2%) that downregulates ACE2 expression by 37% (P = 2.7 × 10 −8) and reduces the risk...

2020年12月30日 · The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different cell types.

2025年3月24日 · The SARS-CoV-2 spike protein interacts with ACE2, a key receptor within the renin-angiotensin-aldosterone system (RAAS), which plays a critical role in maintaining vascular homeostasis, regulating blood pressure, and modulating inflammation. An observational study analyzed the gene expression profiles of RAAS receptors and associated miRNAs in 88 hospitalized COVID-19 patients and 20 healthy ...