初学者如何理解Cox回归和HR值 - 知乎 - 知乎专栏
在队列研究中，Cox回归可以起到两点作用，第一，在多因素模式下，探讨多个影响因素，第二，可以利用多因素，来控制干扰因素（即混杂因素），来探讨目标暴露因素的作用。因 …
Targeting of aryl hydrocarbon receptor-mediated activation of ...
Because the activation of cyclooxygenase-2 (COX-2) expression by AhR ligands may contribute to inflammation and tumorigenesis, we investigated the epigenetic regulation of the COX-2 …
Mutated IL-32θ (A94V) inhibits COX2, GM-CSF and CYP1A1 through AhR…
2025年1月15日 · IL-32θ (A94V) suppresses the expressions of COX-2, GM-CSF, and CYP1A1 by blocking the nuclear translocation of NF-κB and AP-1, as well as inhibiting the activation of the …
AhR-STAT3-HO-1/COX-2 signalling pathway may restrict
Key results: AhR inhibition attenuated hepatic ferroptosis and improved survival of hMSCs. hMSC viability was decreased by iron supplementation or serum from I/R mice. The AhR antagonist …
Cyclooxygenase-2 promoter activation by the aromatic ... - PubMed
The role of the aromatic hydrocarbon receptor (AhR) in transcriptional regulation of the human cyclooxygenase-2 (COX-2) gene remains elusive. We report that the AhR-ligands …
Oxidative stress and inflammation are mediated via aryl …
2023年10月1日 · COX-2 is one of the downstream target genes of AHR, indicating that AHR signalling is associated with oxidative stress and inflammation. Thus, we examined intrarenal …
Low levels of the AhR in chronic obstructive pulmonary disease
2017年7月27日 · Heightened inflammation, including expression of COX-2, is associated with chronic obstructive pulmonary disease (COPD) pathogenesis. The aryl hydrocarbon receptor …
AhR–STAT3–HO-1/COX-2信号通路可能限制铁死亡并改善hMSC在 …
Emerging evidence suggested that ferroptosis may provoke hepatocyte dysfunction and exacerbate damage to the liver microenvironment. Here, we have investigated the contribution …
AhR–STAT3–HO‐1/COX‐2 signalling pathway may restrict …
2023年8月4日 · The results supported the importance of AhR–STAT3–HO1/COX-2 pathway in preventing hMSC from iron-induced ferroptosis. Taken together, these results implied that …
The aryl hydrocarbon receptor as a target of environmental …
2020年7月1日 · AHR-dependent induction of CYP1, AKR, NOX and COX-2 genes can be a source of ROS generation. AHR signaling and NRF2 signaling interact to regulate the …
Pathogenesis of Aryl Hydrocarbon Receptor-Mediated Development of ...
Here, we show that activation of the aryl hydrocarbon receptor (AhR) by 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) resulted in loss of the programmed cell death (apoptosis) …
Functions of the aryl hydrocarbon receptor (AHR) beyond the …
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating adaptive and maladaptive responses toward exogenous and endogenous signals. Research …
Aryl hydrocarbon receptor (AhR)-dependent regulation of
2017年1月12日 · Our data show that the AhR is involved in the selective modulation of miRNA expression by cigarette smoke, and in particular suppressing levels of miR-96, a miRNA …
Aryl hydrocarbon receptor-dependent retention of nuclear HuR
2013年9月27日 · The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to man-made environmental toxicants, has emerged as an endogenous regulator of …
Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in …
2021年3月8日 · Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to known human carcinogens including dioxins can lead to the promotion of breast …
Low levels of the AhR in chronic obstructive pulmonary disease …
2017年7月27日 · Heightened inflammation, including expression of COX-2, is associated with chronic obstructive pulmonary disease (COPD) pathogenesis. The aryl hydrocarbon receptor …
Supplementation of nicotinamide mononucleotide diminishes COX …
2024年3月1日 · NMN suppresses inflammatory responses by activating IDO-kynurenine-AhR pathway. Cyclooxygenase-2 (COX-2) is an inducible enzyme responsible for prostaglandin …
【学术前沿】BJP | 上海药物所发现AhR-铁死亡轴调控间充质干细 …
2023年8月14日 · 肝脏中的 AhR 可通过 STAT3-Hmox1/Ptgs2 通路减少铁死亡，改善肝脏微环境，进而有效提升MSC的暴露量和治疗效果，且AhR抑制剂（CH223191）发挥药效的剂量仅需 …
Epilepsia - Wiley Online Library
3 天之前 · Using multivariate Cox proportional hazards models guided by a directed acyclic graph and adjusted for confounders including past seizure frequency and duration of epilepsy, we …
Low levels of the AhR in chronic obstructive pulmonary disease …
2017年7月27日 · Heightened inflammation, including expression of COX-2, is associated with chronic obstructive pulmonary disease (COPD) pathogenesis. The aryl hydrocarbon receptor …