
CRABP2 Gene - GeneCards | RABP2 Protein | RABP2 Antibody
2024年12月24日 · CRABP2 (Cellular Retinoic Acid Binding Protein 2) is a Protein Coding gene. Diseases associated with CRABP2 include Embryonal Carcinoma and Basal Cell Carcinoma. Among its related pathways are MIF Mediated Glucocorticoid Regulation …
CRABP2 - Wikipedia
Cellular retinoic acid-binding protein 2 is a cytoplasmic binding protein that in humans is encoded by the CRABP2 gene. [5] [6] [7] CRABP2 is structurally similar to CRABP1, but CRABP2 has a lower affinity for retinoic acid (RA). [5]
CRABP2 cellular retinoic acid binding protein 2 [ (human)]
Cellular Retinoic Acid Binding Protein 2 (CRABP2), Up-regulated by HPV E6/E7, Leads to Aberrant Activation of the Integrin beta1/FAK/ERK Signaling Pathway and Aggravates the Malignant Phenotypes of Cervical Cancer. CRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1alpha.
CRABP2 affects chemotherapy resistance of ovarian cancer by
2024年1月9日 · CRABP2 is a nuclear shuttle protein that can transport RA from cytoplasm to nucleus, in which RA interacts with nuclear receptors (RAR/RXR), and regulate gene expression [12]. In...
CRABP2在肿瘤发生发展中的作用研究 - Magtech
2025年3月1日 · 细胞视黄酸结合蛋白2(cellular retinoic acid-binding proteins 2, CRABP2)是一组低相对分子质量的胞内蛋白,其主要生理功能之一是将RA运输到细胞核中,与视黄酸受体(retinoic acid receptor, RAR)结合,从而调控特定的下游信号通路来发挥作用。 研究发现,CRABP2的异常表达与人类恶性肿瘤密切相关,能通过调节诸多生长或凋亡相关通路或关键生物学分子,影响肿瘤的发生、发展。 因此,CRABP2或许可以作为新的肿瘤诊断和预后标志 …
CRABP2重组蛋白—研究其潜在功能 - 哔哩哔哩
2024年2月19日 · 一、CRABP2蛋白基本信息: CRABP2(细胞再生相关蛋白2)是一种结合和转运维生素A的蛋白,属于胞内维生素感受器家族的成员。其分子量约为15 kDa,由13.3 kDa亚基组成。
CRABP2 regulates invasion and metastasis of breast cancer ... - PubMed
2019年8月16日 · Our findings indicate that CRABP2 can suppress invasion and metastasis of ER + breast cancer and promote invasion and metastasis of ER - breast cancer by regulating the stability of Lats1 in vitro and in vivo, and it provides new ideas for breast cancer therapy.
单细胞测序揭示乳腺癌肿瘤免疫微环境特征标志物CRABP2/CD69 …
2023年11月2日 · 提取了两个亚型特异基因,即 crabp2 和 cd69,它们分别在肿瘤富集亚型和免疫浸润亚型中上调。 根据CRABP2和CD69的表达,建立了CRABP2/CD69特征,BrCa样本被重新分为三个亚型,并在多个队列中验证了其对临床结果和 新辅助化疗 (NAT)反应的预测价值,其中CRABP2高CD69 ...
细胞视黄酸结合蛋白 2(CRABP2)基因 | MCE
该蛋白质是一种细胞质到细胞核的穿梭蛋白,可促进 RA 与其同源受体复合物结合并转移至细胞核。 它参与维甲酸信号通路,并与循环低密度脂蛋白胆固醇增加有关。 已发现该基因编码相同 …
CRABP2 regulates infiltration of cancer-associated fibroblasts and ...
2023年12月28日 · Finding biomarkers for immunotherapy is an urgent issue in cancer treatment. Cellular retinoic acid-binding protein 2 (CRABP2) is a controversial factor in the occurrence and development of human tumors. However, there is limited research on the relationship between CRABP2 and immunotherapy response …