2019年1月25日 · Detailed studies at the molecular level revealed that CRBN protects the etoposide-induced cell death by altering the interaction between p53 and Bcl-2/Bcl-X L through its competitive...

MDM2-Protacs选择性结合在MDM2表面的p53位点，可以同时稳定p53蛋白（抑癌基因）和降解靶蛋白，表现出更好的抗癌活性。 但是，MDM2结合配体不易合成获得，这也导致了其应用的有限性。

2019年1月25日 · Here we find that CRBN plays a protective role against DNA damage-induced apoptosis in cell lines and primary cells. Mechanistic studies demonstrate that although CRBN does not affect the ubiquitination and degradation of the tumor suppressor p53, it directly interacts with p53 and therefore, suppresses the interaction between p53 and anti ...

MDM2，全称为双微体同源基因2（mouse double minute 2），是p53（一种强大的肿瘤抑制因子，人类癌症中突变最频繁的基因）的关键负调节因子，在肿瘤中高表达，对肿瘤的发生和发展起到重要的作用。

CRBN depletion enhances the interaction between p53 and Bcl-2/Bcl-XL, reduces mitochondrial membrane potential, increases the cleavage of caspase-3 and poly(ADP-ribose)...

2024年10月9日 · dp53m能够促进E3泛素连接酶CRBN和p53-R175H突变体结合形成三元复合物，进而通过泛素-蛋白酶体途径降解p53-R175H突变体，而对野生型p53蛋白的降解几乎没 ...

CRBN helps the E3 ubiquitin ligase complex target ion channels for ubiquitination and therefore maintains the ion balance and reduces the incidence of ion channel disease. CRBN is a metabolic regulator that directly binds to AMPK and inhibits its function of increasing ATP production and decreasing ATP consumption.

CRBN耗尽增强p53和Bcl-2 / Bcl-X L之间的相互作用，降低线粒体膜电位，增加caspase-3和聚（ADP-核糖）聚合酶1的裂解，从而在依托泊苷处理后促进DNA损伤诱导的细胞系和原代细胞凋亡。

2020年9月18日 · Immunomodulatory drugs (IMiDs) induce the degradation of neosubstrates by interacting with celebron (CRBN) in the cullin E3 ubiquitin ligase complex (CRL4 CRBN). Here, we developed the...

2019年1月25日 · Detailed studies at the molecular level revealed that CRBN protects the etoposide-induced cell death by altering the interaction between p53 and Bcl-2/Bcl-X L through its competitive interaction with p53 but not through the enzymatic function of its associated E3 ligase.