A Cre switch for transgenes. The Cre/lox system is one of the most powerful and versatile tools developed for mouse genetics. It gives mouse researchers sophisticated control over the …

2006年5月18日 · To use Cre-lox technology, an investigator has to produce a Cre-lox mouse, typically by breeding a Cre mouse to a loxP mouse. A Cre mouse contains a Cre recombinase …

You don't have to be a user or developer of cre or floxed mice to appreciate the impact that cre-lox technology has had on biomedical research and genetic engineering. Since its discovery in …

2025年1月21日 · The advent of Cre-lox recombinase technology in mouse models revolutionized the life sciences. It opened the door to elucidating gene function within a defined cell …

A. Research Tools: Cre-Lox and More FAQ. How do Cre-Lox and Tet-on / Tet-off systems work? Click here for an introduction to Tet Expression Systems. Click here for an on demand webinar …

In a previous post I discussed breeding Cre/lox mice to generate tissue-specific and inducible conditional knockout mouse strains. I would now like to continue the discussion of breeding …

Here we dispel four common Cre-lox myths: Myth #1. Cre strains have excision activity only in the intended cell type or tissue. You expect that a strain where Cre is driven by a brain-specific …

With tissue-specific Cre-lox KO models, the genotype of the mice that you generally want to evaluate ishomozygous for your floxed allele (fl/fl) and positive for Cre (cre+). (Typically, only …

Most mouse geneticists who work with Cre-lox mice probably are familiar with the FLP-FRT system. Like Cre, FLP is a tyrosine recombinase, but it originates from the …

The Cre/lox system has become the cornerstone of modern mouse genetics because it enables sophisticated control over the timing and location of gene expression. This is the first in a …