crem 抑制剂是一类化学化合物，旨在选择性地、逆转录地靶向被称为 camp 应答元件调节剂 (crem) 的转录因子。 CREM 是基因表达的重要调节因子，对细胞中的 cAMP 信号通路做出反应。

Inhibition of PDE4 by rolipram and HT-0712 activates cAMP/CREB signaling, enhances cognitive function, and restores motor skill after cerebral ischemia 102. Notably, PDE4 inhibitors facilitate behavioral recovery and cortical reorganization to a significantly greater level when comparing to the rehabilitation alone 102.

2020年7月1日 · Phosphodiesterase-4 (PDE4) functions as a critical intracellular enzyme in immune cells and keratinocytes through the hydrolysis of cAMP. Inhibition of PDE4 has been considered as an effective therapeutic strategy in multiple inflammatory diseases.

2021年11月1日 · PDE4 inhibition by arctigenin resulted in elevation of intracellular cyclic adenosine monophosphate (cAMP) and phosphorylation of cAMP-response element binding protein (CREB), which were largely blocked through intervention of protein kinase A (PKA) activity by H89 treatment or reduction of protein expression by siRNA transfection.

This study investigated the effect of a PDE4 inhibitor on the expression of the inducible cAMP early repressor (ICER), which is an endogenous inhibitor of CRE-mediated transcription, in osteoblastic cells. RT-PCR analysis revealed that rolipram, a PDE4 inhibitor, stimulates the ICER mRNA in a dose dependent manner.

2024年3月7日 · So far, PDE4 is the best-described PDE in T-cells and the first PDE that is currently targeted in clinical practice to treat autoimmune diseases. But also, other PDE families harbor additional therapeutic potential. PDE2A is a dual-substrate phosphodiesterase which is selectively upregulated in Tcon upon activation.

2023年11月21日 · Phosphodiesterase 4 (PDE4), an enzyme expressed in the dorsal hippocampus (DH), hydrolyzes the cAMP, limiting the PKA-induced CREB phosphorylation (pCREB) and BDNF...

2024年12月24日 · CREM (CAMP Responsive Element Modulator) is a Protein Coding gene. Diseases associated with CREM include Female Stress Incontinence and Infertility. Among its related pathways are Activation of cAMP-Dependent …

2023年12月16日 · pde4抑制剂通过抑制pde4对camp的水解，从而提高胞内camp的浓度。 高水平的cAMP能激活磷酸激酶A(protein kinase A，PKA)和cAMP激活的交换蛋白1/2(exchange protein activated by cAMP1/2，Epac1/2)，从而调节多种信号通路[11]。

PDE4 inhibitors developed for the treatment of IBD. Patients suffering from Crohn's diseases (CD) and UC mostly manifest with severe diarrhea, fecal urgency, body weight loss, hematochezia, incontinence, and abnormal pain and even with fever caused by plethoric inflammation in the gut that lasts for weeks to months (Kumar et al., 2013). The ...