The goal of this study is to establish a Cre/loxP rat resource for conditional and physiologically predictive rat models of human diseases. The laboratory rat (R. norvegicus) is a central experimental animal in several fields of biomedical research, ...

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2011年12月8日 · We first generated multiple BAC transgenic rat lines expressing Cre recombinase in tyrosine hydroxylase (TH) neurons (Experimental Procedures) and tested the specificity and potency of these lines for potential optogenetic experiments (Figure 1, …

2004年7月9日 · Here we report the Cre/LoxP transgenic rat system, demonstrating conditional chromosomal translocation both in the fertilization and adult stage, spatio-temporal gene controlling by catheter-based adenoviral gene transfer, and …

2020年10月20日 · We are offering a complete range of custom conditional knockout (cKO) or conditional knockin (cKI) rat models alongside the Cre driver strains needed to develop physiologically relevant models of human diseases, available to researchers worldwide.

2004年7月9日 · Here we report the Cre/LoxP transgenic rat system, demonstrating conditional chromosomal translocation both in the fertilization and adult stage, spatio-temporal gene controlling by catheter-based adenoviral gene transfer, and …

2019年9月16日 · Here, we describe the generation and characterization of a new transgenic rat strain in which conditional expression of the ZsGreen fluorescent protein gene requires the presence of exogenous Cre...

2002年9月1日 · Creatine has been shown to increase the total muscle mass. In this study, we investigated the effect of oral creatine monohydrate supplementation on cross-sectional area of type I, IIA and IIB fibers of gastrocnemius, extensor digitorum longus - EDL and soleus muscles from male Wistar rats subjected …

The goal of this study is to establish a Cre/loxP rat resource for conditional and physiologically predictive rat models of human diseases. The laboratory rat (R. norvegicus) is a central experimental animal in several fields of biomedical research, such as cardiovascular diseases, aging, infectious …

Given the higher facility fees associated with rats, the creation of all strains necessary to achieve a Cre-lox rat strain can quickly become cost- or space-prohibitive. To address this issue, Cyagen is building a repository of Cre models, including rat lines, available to researchers worldwide.