
CRKL Gene - GeneCards | CRKL Protein | CRKL Antibody
2024年12月24日 · CRKL (CRK Like Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRKL include Digeorge Syndrome and Hemorrhage, Intracerebral. …
CRKL - Wikipedia
Crk-like protein is a protein that in humans is encoded by the CRKL gene. [5][6] v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has …
Crk and CrkL adaptor proteins: networks for physiological and ...
2009年5月10日 · Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting …
CRKL CRK like proto-oncogene, adaptor protein [ (human)]
Data show that miR-193b, by directly targeting focal adhesion kinase (FAK), CRK-like proto-oncogene (CRKL), and methionine sulfoxide reductase A (MSRA), regulates focal adhesion …
CRK 样原癌基因、衔接蛋白(CRKL)基因 | MCE
该基因编码含有 SH2 和 SH3 (Src 同源) 结构域的蛋白激酶,已显示可激活 Ras 和 JUN 激酶信号通路并以 Ras 依赖性方式转化成纤维细胞。 它是 Bcr-Abl 酪氨酸激酶的底物,在 Bcr-Abl 的 …
【合作文章,IF=25.7】CyTOF发现CRKL通过介导肝癌中肿瘤相关 …
近期,复旦大学李辉、郭磊、叶青海、樊嘉及中国台湾中国医科大学洪明奇等合作在 Journal of Hepatology(IF=25.7) 在线发表题为 “ CRKL dictates anti-PD-1 resistance by mediating …
CRKL regulates alternative splicing of cancer-related genes in …
2019年5月27日 · CRKL is tightly linked to leukemia via its binding partners BCR-ABL and TEL-ABL, upregulated in multiple types of human cancers, and induce cancer cell proliferation and …
J Hepatol | 复旦大学李辉/郭磊/叶青海/樊嘉合作等发现CRKL调控 …
2024年2月25日 · CRKL过表达通过动员肿瘤相关中性粒细胞 (TANs)阻断CD8+ T细胞的浸润和功能而使抗PD-1治疗效果无效。 PD-L1+ TANs被发现是TANs的一个重要子集,受CRKL表达调 …
接头蛋白Crk与肿瘤 - 中国生物化学与分子生物学报
Crk是一种重要的细胞内信号接头蛋白,含有SH2和SH3结构域,在信号传递过程中不仅承上启下,对信号强度还有着调控作用.迄今主要发现了4种Crk分子,即v Crk、CrkⅠ、CrkⅡ和CrkL …
CRKL重组蛋白:研究细胞信号传导的重要工具 - 哔哩哔哩
而Crk样蛋白 (CRKL)作为一种蛋白质信号调控分子,扮演着重要的角色。 本文将介绍CRKL的基本特征,重组蛋白的制备以及其在科学研究中的应用。 艾普蒂生物 目录号:PA1000-713. 一 …