We have isolated and characterised a novel human protein kinase, Cdc2-related kinase with an arginine/serine-rich (RS) domain (CrkRS), that is most closely related to the cyclin-dependent kinase (CDK) family. CrkRS is a 1490 amino acid protein, …

2024年12月24日 · CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include Prostate Cancer, Hereditary, 1 and Hereditary Breast Ovarian Cancer Syndrome. Among its related pathways are Gene expression (Transcription) and Formation of HIV elongation complex in the absence of HIV Tat.

CrkRS (Cdc2-related kinase, Arg/Ser), or cyclin-dependent kinase 12 (CKD12), is a serine/threonine kinase believed to coordinate transcription and RNA splicing. While CDK12/CrkRS complexes were known to phosphorylate the C-terminal domain (CTD) of RNA polymerase II (RNA Pol II), the cyclin regulatin …

2001年7月15日 · We have isolated and characterised a novel human protein kinase, Cdc2-related kinase with an arginine/serine-rich (RS) domain (CrkRS), that is most closely related to the cyclin-dependent kinase (CDK) family. CrkRS is a 1490 amino acid protein, the largest CDK-related kinase so far isolated.

Plasmid CRKRS from Dr. Eugene Yeo's lab contains the insert CRKRS and is published in Nat Struct Mol Biol. 2020 Oct;27 (10):989-1000. doi: 10.1038/s41594-020-0477-6. Epub 2020 Aug 17. This plasmid is available through Addgene.

CrkRS is a Cdc2-related protein kinase that contains an arginine- and serine-rich (SR) domain, a characteristic of the SR protein family of splicing factors, and is proposed to be involved in RNA processing. However, whether it acts together with a cyclin …

2001年7月15日 · Anti-CrkRS immunoprecipitates phosphorylate the C-terminal domain of RNA polymerase II in vitro, suggesting that CrkRS may be a novel, conserved link between the transcription and splicing machinery. We have isolated and characterised a novel human protein kinase, Cdc2-related kinase with an arginine/serine-rich (RS) domain (CrkRS), that is ...

2001年8月1日 · We have isolated and characterised a novel human protein kinase, Cdc2-related kinase with an arginine/serine-rich (RS) domain (CrkRS), that is most closely related to the cyclin-dependent kinase...

2023年1月1日 · Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases that aptitudinally modulate diverse cellular biological functions by binding to their activating cyclin partners, mostly during cell cycle progression and gene transcription. [1, 2] At present, CDKs are subdivided into two dominant classifications: cell cycle-associa...

CrkRS (Cdc2-related kinase, Arg/Ser), or cyclin-dependent kinase 12 (CKD12), is a serine/threonine kinase believed to coordinate transcription and RNA splicing. While CDK12/CrkRS complexes were known to phosphorylate the C-terminal domain (CTD) of RNA polymerase II (RNA Pol II), the cyclin regulating this activity was not known.