2023年10月17日 · Bispecific CAR-T cell therapy has been proposed to mitigate some limitations of single-target CAR-T cells. CS1, also known as CD319, SLAMF7, and CRACC, is a cell …

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In this study, we determined whether CS1, a surface protein that is highly expressed on MM cells, can be targeted by CAR NK cells to treat MM. We successfully generated a viral construct of a …

2022年4月14日 · High CS1 (SLAMF7) expression on myeloma cells and limited expression on normal cells makes it a promising target for CAR-T therapy. The CS1 protein has two …

2021年10月9日 · In this study, we aimed to develop novel CS1 CAR-T cells and bispecific CS1-BCMA CAR-T cells to specifically target multiple myeloma. We generated a new CS1 (CD319, …

2020年5月8日 · Chimeric antigen receptor (CAR)-T cell therapy has shown remarkable clinical efficacy against B-cell malignancies, yet marked vulnerability to antigen escape and...

2019年5月11日 · 王博士的团队开发了CS1 CAR-T，并在临床前和转化研究中成功进行了测试。 CS1是Bristol-Myers Squibb和AbbVie的多发性骨髓瘤抗体Empliciti（elotuzumab）的靶点， …

2002年2月26日 · The four-seater CS1 convertible concept car is clearly a genuine BMW, a fully-fledged member of the family. But at the same time it boasts its unique, independent character …

95%以上的骨髓瘤细胞高度表达cs1，且骨髓细胞、造血干细胞和大多数健康组织中几乎检测不到cs1的表达，因此cs1可作为mm car-t疗法的重要靶标 [5,6,7] 。

High CS1 (SLAMF7) expression on myeloma cells and limited expression on normal cells makes it a promising target for CAR-T therapy. The CS1 protein has two extracellular domains - the …