2024年12月24日 · CSDE1 (Cold Shock Domain Containing E1) is a Protein Coding gene. Diseases associated with CSDE1 include Developmental Malformations-Deafness-Dystonia Syndrome and Rasopathy. Among its related pathways is Validated targets of C-MYC transcriptional repression.

Cold shock domain-containing protein E1 is a protein that in humans is encoded by the CSDE1 gene. [5][6][7]

Title: Cold Shock Domain Containing E1 (CSDE1) Protein is Overexpressed and Can be Targeted to Inhibit Invasiveness in Pancreatic Cancer Cells. Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy.

Here, we report a significant burden of heterozygous, likely gene-disrupting variants in CSDE1 (encoding a highly constrained RNA binding protein) among patients with autism and related neurodevelopmental disabilities.

CSDE1 promotes miR-451 biogenesis. Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Reduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer. Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1.

This gene has 53 transcripts (splice variants), 240 orthologues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 208.0), thyroid (RPKM 164.2) and 25 other tissues. 启用 RNA 茎环结合活性。 参与 IRES 依赖性病毒翻译启动；核转录的 mRNA 分解代谢过程，不衰变；和应力颗粒组装。 位于高尔基体；胞质溶胶；和质膜。 CRD 介导的 mRNA 稳定性复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

2024年4月10日 · This review focuses on one such modulator, the protein CSDE1, and its pivotal role in regulating cancer hallmarks. We discuss context-specific functions of CSDE1 in tumor development, its mechanisms of action, and highlight features that support its role as a …

CSDE1 (cold shock domain containing E1) gene is located upstream of the N-RAS locus, and codes for an RNA-binding protein named Upstream of N-Ras (UNR). In cancer, CSDE1 has been shown to regulate c-Fos, c-Myc, Pten, Rac1, or Vimentin.

Guo et al., 2019 initially targeted the coding region of the CSDE1 gene using a modified single-molecule molecular inversion probe approach among 4,045 ASD probands from the Autism Clinical and Genetic Resources in China (ACGC) cohort and identified de novo likely gene-disruptive variants in three simplex families.

4 天之前 · Plasma cell differentiation is governed by a gene expression program, for which transcriptional regulators are mostly known but other regulatory elements, such as RNA-binding proteins remain ...