2024年12月24日 · CTBP1 (C-Terminal Binding Protein 1) is a Protein Coding gene. Diseases associated with CTBP1 include Hypotonia, Ataxia, Developmental Delay, And Tooth Enamel Defect Syndrome and Wolf-Hirschhorn Syndrome. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma …

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. [5] . CtBP1 is one of two CtBP proteins, the other protein being CtBP2. [6] The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins.

C-terminal binding proteins (CtBP1/2) are transcriptional coregulators that play a significant role during vertebrate neurodevelopment. This systematic review aims to identify case reports with genetic variants in CTBP1 and CTBP2 associated with ...

2021年7月13日 · CtBP1 protects the integrity of stalled forks under metabolic stress condition during prolonged periods of replication, whereas CtBP2 acts a dominant role in stability of DNA replication recovery.

CtBP1 promotes tumour-associated macrophage infiltration and progression in non-small-cell lung cancer. CtBP determines ovarian cancer cell fate through repression of death receptors. CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.

CtBP1 overexpression is known to be pro-tumorigenic and affects the regulation of gene networks associated with “cancer hallmarks” and malignant behavior including: increased cell survival, proliferation, migration, invasion, and the epithelial-mesenchymal transition (EMT).

2018年3月23日 · The CTBP1 gene encodes a transcriptional regulator that interacts with chromatin-modifying enzymes to modulate gene expression in multiple cellular pathways. CTBP1 is thought to function mainly in transcriptional repression through recruitment of histone-modifying enzymes such as histone deacetylases and methyltransferases (summary by Beck et ...

2023年10月31日 · 简介 C 末端结合蛋白 1 (CtBP1) 是一种多功能蛋白，具有明确的细胞核转录辅助抑制因子和细胞质膜裂变调节因子的作用。尽管已报道 CtBP1 基因异常会导致神经发育障碍，但 CtBP1 的生理作用和表达谱仍有待阐明。

Introduction: C-terminal-binding protein 1 (CtBP1) is a multi-functional protein with well-established roles as a transcriptional co-repressor in the nucleus and a regulator of membrane fission in the cytoplasm. Although CtBP1 gene abnormalities have been reported to cause neurodevelopmental disorders, the physiological role and expression ...

Ubiquitous expression in spleen (RPKM 9.3), prostate (RPKM 7.1) and 25 other tissues. 该基因编码的蛋白质可与腺病毒 E1A 蛋白的 C 末端结合。 这种磷蛋白是一种转录抑制因子，可能在细胞增殖过程中发挥作用。 这种蛋白质和第二个密切相关的基因 CTBP2 的产物可以二聚化。 这两种蛋白质还可以与参与发育过程中基因表达调节的多梳组蛋白复合物相互作用。 来自该基因的转录本的可变剪接导致多个转录本变体。 [RefSeq 提供，2008 年 7 月]