CTGF, also known as CCN2 or connective tissue growth factor, [5][6] is a matricellular protein of the CCN family of extracellular matrix -associated heparin -binding proteins (see also CCN intercellular signaling protein). [7][8][9] CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogen...

2023年5月15日 · 结缔组织生长因子(connective tissue growth factor，CTGF)是一种新发现的可刺激成纤维细胞增殖和胶原沉积的细胞因子，也称为CCN2，是细胞外基质相关肝素结合蛋白的CCN家族的细胞质蛋白,是1991年BRADHAM等首先在人…

2020年10月19日 · 结缔组织生长因子(Connective tissue growth factor, CTGF), 也被称为fisp12, β IG-M2, 和IGF-BP8,是一种富含半胱氨酸的分泌生长因子，属于CCN (cyr61, CTGF, nov)家族。最早于1991年从血清激活的NIH3T3细胞中被分离出来并命名为 fisp12 (fibroblast-inducible secreted protein-12成纤维细胞诱导的 ...

Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation, adhesion and angiogenesis, as well as multiple pathologies, such as tumor development and tissue fibrosis.

2012年6月6日 · CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis.

2024年4月2日 · 结缔组织生长因子（CTGF）蛋白是一种多功能、多效性的蛋白质，属于CCN（Cyr61/CTGF/NOV）家族成员之一。 它在细胞增殖、分化、迁移、粘附以及细胞外基质合成等多个方面发挥着重要的调控作用。 近年来，随着对 CTGF蛋白 研究的不断深入，其在疾病发生发展中的作用也逐渐被揭示。 首先，CTGF蛋白在细胞增殖和分化中扮演着重要角色。 它能够通过激活多条信号通路，如整合素、TGF-β等，促进细胞的增殖和分化。 这种功能使得CTGF在 …

The overexpression of a matricellular protein, connective tissue growth factor (CTGF), is a hallmark of fibrosis in multiple tissues in the mediation of the pro-fibrotic effects of tumor growth factor-β (TGF-β) . CTGF is a primary mediator of TGF-β-induced pulmonary fibrosis.

ctgf表现出与tgf-β不同的生物学活性，作用比较单一，主要介导tgf-β的促纤维化作用，并且它只在 间质细胞 中表达，其作用也只局限于结缔组织。因此，靶向ctgf的抗肝纤维化治疗不影响tgf-β抗炎和调节免疫功能，是一个较阻断tgf-β更有效和特异的靶点。

Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved in different biological processes, such as cell proliferation, angiogenesis, and wound healing, as well as multiple pathologies, such as tumor development and tissue fibrosis.

2021年3月10日 · Connective tissue growth factor (CTGF), also known as CCN2, is a member of the CCN protein family of secreted proteins with roles in diverse biological processes....