CTSB is a membership organization formed to facilitate community production of locally originated, non-commercial television and other media.

Cathepsin B is synthesized on the rough endoplasmic reticulum as a preproenzyme of 339 amino acids with a signal peptide of 17 amino acids. [14] [15] Procathepsin B of 43/46 kDa is then transported to the Golgi apparatus, where cathepsin B is formed.Mature cathepsin B is composed of a heavy chain of 25-26 kDa and a light chain of 5kDa, which are linked by a dimer of disulfide.

Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and aging animal models. Deletion of the CTSB gene resulted in significant ...

Role of CTSB in cell death. In the presence of LMP, CTSB is released into the cell matrix, leading to lysosome-dependent death, and triggers the activation of the apoptotic cascade by releasing Cyt-C. CTSB also independently leads to apoptosis independent of the caspase pathway.

Dec 24, 2024 · CTSB (Cathepsin B) is a Protein Coding gene. Diseases associated with CTSB include Keratolytic Winter Erythema and Hyperparathyroidism, Neonatal Severe.Among its related pathways are Collagen chain trimerization and Innate Immune System.Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity.

Apr 5, 2024 · Cancer remains the major threat to human health, with 19.3 million new cancers and approximately 10 million deaths in 2020 alone [1].CTSB is a lysosomal cysteine protease closely related to tumor infiltration and metastasis, inflammation, angiogenesis, apoptosis, and autophagy [2].However, the specific mechanism by which CTSB participates in tumorigenesis is still …

Mar 11, 2022 · CTSB is remarkably highly-expressed in HGG, isocitrate dehydrogenase (IDH) wildtype, 1p19q non-codeletion type and O 6-methylguanine-DNA methyltransferase (MGMT) promoter unmethylation gliomas. To ...

Feb 9, 2025 · Official Symbol CTSB provided by HGNC Official Full Name cathepsin B provided by HGNC Primary source HGNC:HGNC:2527 See related Ensembl:ENSG00000164733 MIM:116810; AllianceGenome:HGNC:2527 Gene type

Cathepsin B (CTSB) is a member of the cysteine protease family, primarily responsible for degrading unnecessary organelles and proteins within the acidic milieu of lysosomes to facilitate recycling. Recent research has revealed that CTSB plays a multifaceted role beyond its function as a proteolytic …

This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the …