Cathepsin B intracellular trafficking. CTSB is originally synthesized as a preproenzyme in the ER-associated polyribosome. Upon translocation to the ER, CTSB pre-peptide is cleaved to form a …

2025年1月23日 · This figure depicts key factors related to study design, participant characteristics, exercise protocols, and methodologies that may moderate the associations …

The RNA single-cell-type specificity indicated that CTSB was most expressed in the blood and immune cells, especially in the Hofbauer cells, Kupffer cells, macrophages, and monocytes ( …

2020年12月28日 · Our results indicate that CTSB localizes in the caveolae and participates in the pericellular degradation of ECM in TM cells. We also report here a novel role of CTSB in …

Enzymatic inhibition assays indicated that the CTSB IgG could inhibit CTSB activity with a Ki of 169 ± 80 nM (Figure 2A), supporting that fusion of the propeptide into the CDR3H region …

More than 200 million people have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 4 million deaths have been reported worldwide to date. …

2017年12月5日 · Here, we show that BAG2 promotes cancer progression by regulating the dual function of CTSB in TNBC cells, implicating the potential for BAG2 to serve as a specific target …

The cytoplasmic CTSB-induced cascade of events that eventually contributes to cell death. When released from the damaged neurons into the extracellular space in a large quantity, CTSB can …

2025年3月13日 · We demonstrate that elevated lysosomal cathepsin B (CTSB) levels and CTSB leakage to the cytoplasm triggers amyloidogenesis in two neurological LSDs.

2010年9月6日 · To assess expression of the CTSB transgene in mammary tumors, we examined the histological localization, protein levels and proteolytic activity of CTSB (Figure 1). …