Proteintech's Rabbit Polyclonal Cathepsin B antibody is validated in WB, IHC, ELISA and shows reactivity with human, mouse samples.

2023年11月3日 · Orthotopic liver implantation of BMI1 high TICs into mice generates tumors and triggers CTSB mediated bile duct invasion to form tumor thrombus, while CTSB inhibitor treatment prohibits BDTT...

2024年8月7日 · Using cell-specific proteomics, we show that LV-proximal GBM prevents neuronal maturation of NSCs through induction of senescence. In addition, GBM brain tumor–initiating cells (BTICs) increase expression of cathepsin B (CTSB) upon interaction with NPCs.

2013年10月20日 · To address tumor biological processes affected by CTSB-shRNA, we investigated proliferation and apoptosis in vivo by PCNA IHC analysis and TUNEL assay (Figure 4C). CTSB-shRNA treated tumor did not show significantly higher percentage of TUNEL-positive nuclei than tumors treated with PBS, Lipo, or NC group (6 ± 1.3 versus 6 ± 1, 7 ± 1.5, or 7 ...

2016年2月20日 · To explore the exact role of CTSB in HCC, we investigated whether the expression of CTSB protein is different between tumor tissues and normal tissues, whether CTSB plays an important role in the development and progression of HCC, and whether CTSB is a prognostic factor in HCC after curative surgical treatment.

2025年3月13日 · We demonstrate that elevated lysosomal cathepsin B (CTSB) levels and CTSB leakage to the cytoplasm triggers amyloidogenesis in two neurological LSDs.

组织蛋白酶B（Cathepsin B）是一种溶酶体半胱氨酸蛋白酶，常被简称为CathB或CTSB。 这种酶在正常生理状态下负责降解受损蛋白质，维持细胞稳态，但在病理条件下可能促进肿瘤侵袭与炎症反应。

Cathepsin B (D1C7Y) XP ® Rabbit mAb recognizes endogenous levels of total cathepsin B protein. This antibody detects the heavy chain subunit of cathepsin B. Human, Mouse, Rat. Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the heavy chain subunit of human cathepsin B protein.

CTSB (Cathepsin B) is also named as CPSB and belongs to the peptidase C1 family. It participates in intracellular degradation and turnover of proteins.