2024年12月24日 · CTSG (Cathepsin G) is a Protein Coding gene. Diseases associated with CTSG include Vasculitis and Gingivitis. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Response of Mtb to phagocytosis.

组织蛋白酶G （英文：Cathepsin G）是一种在人体中由CTSG 基因 编码的 蛋白质。 它是储存在 嗜天青颗粒 细胞中的 糜蛋白酶 家族的三种 丝氨酸蛋白酶 之一，也是肽酶S1蛋白家族的成员。 组织蛋白酶G在消除细胞内 病原体 和分解 炎症 部位的组织以及抗炎反应中起重要作用。 [5][6][7][8] CTSG基因位于 14号染色体 q11.2，由5个 外显子 组成。 催化三联体 的每个 残基 都位于一个单独的外显子上。 通过扫描整个 编码区 已鉴定出五个 基因多态性。 [9] 组织蛋白酶G是通过 基因 …

Cathepsin G is a protein that in humans is encoded by the CTSG gene. It is one of the three serine proteases of the chymotrypsin family that are stored in the azurophil granules, and also a member of the peptidase S1 protein family. Cathepsin G plays an important role in eliminating intracellular pathogens and breaking down tissues at ...

编码的蛋白酶具有与胰凝乳蛋白酶 C 相似的特异性，可能参与吞噬病原体的杀灭和消化，以及炎症部位的结缔组织重塑。 此外，编码的蛋白质是抗菌的，对金黄色葡萄球菌和淋病奈瑟菌具有杀菌活性。 该基因存在利用替代聚腺苷酸化信号的转录变体。 [RefSeq 提供，2014 年 9 月] The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes.

2021年5月20日 · We report that NSPs cathepsin G (CTSG), neutrophil elastase (ELANE) and proteinase 3 (PRTN3) jointly catalyze H3ΔN in monocytes. NSPs are localized to the chromatin, generating H3ΔN that is...

2024年12月10日 · Title: CTSG Suppresses Colorectal Cancer Progression through Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway. Downregulation of interleukin 36gamma and its cleaver cathepsin G following treatment with narrow-band ultraviolet B …

Cathepsin G belongs to the neutrophil serine proteases family, known for its function in killing pathogens. Studies over the past several years indicate that cathepsin G has important effects on inflammation and immune reaction, and may be a key factor in the pathogenesis of some autoimmune diseases.

Results show that cathepsin G (CTSG) N125S (AG) genotype was significantly more frequent among osteomyelitis patients than controls. High CTSG expression is associated with antidiastole of tuberculous pleural effusion. Cathepsin G in human atherosclerotic lesions is largely derived from monocytes.

CTSG impedes the proliferation and metastasis of HNSC in vivo and in vitro. CTSG is potential to act as a cancer suppressor in HNSC by focusing on the JAK2/STAT3 signaling pathway, indicating its possible use as a diagnostic marker and treatment target for HNSC.

2024年12月26日 · Results: CTSG is expressed at low levels and serves as a prognostic marker in NSCLC. The downregulation of CTSG expression was associated with lymph node metastasis, tumor stage, and immune cell infiltration. CTSG inhibits NSCLC cell proliferation, migration, and invasion as well as tumor growth in nude mice.