Cathepsin G is a protein that in humans is encoded by the CTSG gene. It is one of the three serine proteases of the chymotrypsin family that are stored in the azurophil granules, and also a member of the peptidase S1 protein family.

Dec 24, 2024 · CTSG (Cathepsin G) is a Protein Coding gene. Diseases associated with CTSG include Vasculitis and Gingivitis. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Response of Mtb to phagocytosis.

Cathepsin G belongs to the neutrophil serine proteases family, known for its function in killing pathogens. Studies over the past several years indicate that cathepsin G has important effects on inflammation and immune reaction, and may be a key factor in the pathogenesis of some autoimmune diseases.

Colorectal cancer (CRC) is the most common gastrointestinal tumor worldwide, which is a severe malignant disease that threatens mankind. Cathepsin G (CTSG) has been reported to be associated with tumorigenesis, whereas its role in CRC is still unclear. This investigation aims to determine the function of CTSG in CRC.

CTSG impedes the proliferation and metastasis of HNSC in vivo and in vitro. CTSG is potential to act as a cancer suppressor in HNSC by focusing on the JAK2/STAT3 signaling pathway, indicating its possible use as a diagnostic marker and treatment target for HNSC.

CTSG is expressed at low levels and serves as a prognostic marker in NSCLC. The downregulation of CTSG expression was associated with lymph node metastasis, tumor stage, and immune cell infiltration. CTSG inhibits NSCLC cell proliferation, migration, and invasion as well as tumor growth in nude mice.

CatG is an endoprotease that belongs to the S1 class of serine proteases. The CatG gene (CTSG) is located on chromosome 14q11.2 and exhibits a genomic structure similar to that of neutrophil elastase (NE), with five exons and four introns, covering 2.7 kbp of genomic DNA.

Dec 10, 2024 · Title: CTSG Suppresses Colorectal Cancer Progression through Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway. Downregulation of interleukin 36gamma and its cleaver cathepsin G following treatment with narrow-band ultraviolet B …

Results show that cathepsin G (CTSG) N125S (AG) genotype was significantly more frequent among osteomyelitis patients than controls. High CTSG expression is associated with antidiastole of tuberculous pleural effusion. Cathepsin G in human atherosclerotic lesions is largely derived from monocytes.

May 20, 2021 · We report that NSPs cathepsin G (CTSG), neutrophil elastase (ELANE) and proteinase 3 (PRTN3) jointly catalyze H3ΔN in monocytes. NSPs are localized to the chromatin, generating H3ΔN that is...