Cathepsin L plays a key role in SARS-CoV-2 infection in humans …
2021年3月27日 · CTSL functionally cleaved the SARS-CoV-2 spike protein and enhanced virus entry, as evidenced by CTSL overexpression and knockdown in vitro and application of CTSL …
Cathepsin L plays a key role in SARS-CoV-2 infection in humans …
2021年3月27日 · CTSL functionally cleaved the SARS-CoV-2 spike protein and enhanced virus entry, as evidenced by CTSL overexpression and knockdown in vitro and application of CTSL …
Structure-based design of pan-coronavirus inhibitors targeting …
2024年3月6日 · Host-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging coronaviruses. Cathepsin L …
Cas13d knockdown of lung protease Ctsl prevents and treats
2022年7月25日 · Here we describe a chemically engineered nanosystem encapsulating CRISPR–Cas13d, developed to specifically target lung protease cathepsin L (Ctsl) messenger …
Potential drug discovery for COVID-19 treatment targeting …
2022年1月1日 · In the current study, we revealed that the lentivirus expressing human CTSL (Lv-CTSL) significantly upregulated CTSL protein level and enhanced SARS-CoV-2 pseudovirus …
Targeting cathepsins: A potential link between COVID-19 and …
2021年9月29日 · Pharmacological inhibitions of the CTSB/L could be a potential therapeutic target to block the virus entry as well as to mitigate the brain disorders. To this end, we utilized …
Expressions and significances of CTSL, the target of COVID-19 …
We investigated the association between the expression level of CTSL and overall survival in Glioblastoma multiforme (GBM) patients, to better understand the possible route and risks of …
SARS-CoV-2 Spike Protein Induces Time-Dependent CTSL
2024年7月7日 · The study highlights the importance of cathepsin L and lysosomal proteases in the SARS-CoV-2 spike protein internalization and suggests the potential of lysosomal …
Expressions and significances of CTSL, the target of COVID
2021年11月22日 · We evaluated the relationship between the expression of CTSL and the prognosis of GBM patients who susceptibility to COVID-19. In addition, TIMER database was …
Novel cleavage sites identified in SARS-CoV-2 spike protein reveal ...
2022年6月6日 · Recently, we found that in SARS-CoV-2-infected patients, the circulating blood level of CTSL is highly correlated with the severity and course of COVID-19 symptoms. We …