组织蛋白酶L ( cathepsin L，CTSL) 是溶酶体半胱氨酸蛋白酶家族的主要成员，具有非常独特的合成和转运方式。溶酶体CTSL，含有信号肽，并且是从ORF 第1个AUG 起始位点开始翻译。

2021年3月27日 · Here, for the first time, we report the crucial role of cathepsin L (CTSL) in patients with COVID-19. The circulating level of CTSL was elevated after SARS-CoV-2 infection and was positively...

2021年3月23日 · Cathepsin B (CTSB) and L (CTSL) are cysteine proteases, and Cathepsin D (CTSD) is an aspartic protease 8. These cathepsins are major lysosomal proteases and are widely expressed in endosomes and...

2017年6月15日 · CTSL and CTSB levels increased with the Child-Pugh stage of liver cirrhosis and correlated with total bilirubin content (r=0.4/0.2; P≤0.05). CTSL, CTSB, and their combination had a high diagnostic accuracy (area under the curve: 0.91, 0.89 and 0.96, respectively) for distinguishing patients from controls.

2024年5月22日 · These results confirmed that a loss of CTSB, CTSD, and CTSL in SH-SY5Y and CTSB, CTSD, CTSL, and CTSZ in HeLa cells led to dysregulation of certain proteins that had been found by proteome analysis. Also, it revealed that re-transfection of the missing CTSs into the KO cells restored their activity and partially rescued upregulated proteins ...

2025年2月19日 · 为解决急性胰腺炎（AP）发病机制及治疗难题，德国格赖夫斯瓦尔德大学研究人员探究 CST3 在 AP 中的作用。 研究发现 CST3 调控 CTSB 和 CTSL 活性，其变化影响 AP 进程。 该研究为 AP 治疗提供新靶点，推荐科研读者阅读。 急性胰腺炎（AP）是一种常见且可能致命的胃肠道疾病，全球每年每 10 万人中就有 13 - 45 人发病，它也是胃肠道疾病住院的主要原因之一，给医疗系统带来了沉重的负担。 目前，针对 AP 还没有有效的病因治疗方法，这让医生们在 …

2023年11月29日 · 研究团队以TMPRSS2和CTSB/CTSL为研究对象，通过高通量筛选发现了多种具有靶向能力的强效抑制剂，并在细胞水平上展现出nM量级的抗病毒效果。 进一步研究团队利用X-射线晶体学方法解析了上述多种抑制剂与其相应蛋白靶点的复合物结构，揭示了其精细的结合抑制模式。 值得关注的是TMPRSS2与抑制剂的复合物结构首次揭示了TMPRSS2完整胞外域的结构 …

2015年11月24日 · Within the network, certain proteases such as cathepsin B (CTSB) and CTSL represent highly integrated nodes whereas others, such as CTSH, CTSK or CTSZ, represent more discrete activities.

2024年12月24日 · CTSL (Cathepsin L) is a Protein Coding gene. Diseases associated with CTSL include Middle East Respiratory Syndrome and Covid-19. Among its related pathways are Early SARS-CoV-2 Infection Events and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include histone binding and cysteine-type peptidase activity.

Our study demonstrates that under homeostatic conditions CTSB cleaves the calcium channel MCOLN1/TRPML1 in the lysosomes, maintaining suppression of the transcription factor TFEB and reducing expression of lysosomal and autophagy-related proteins. This response controls the number of lysosomes and autophagosomes in the cell.