2024年12月24日 · CTSL (Cathepsin L) is a Protein Coding gene. Diseases associated with CTSL include Middle East Respiratory Syndrome and Covid-19. Among its related pathways are Early SARS-CoV-2 Infection Events and Gene expression (Transcription). Gene Ontology (GO) annotations related to this gene include histone binding and cysteine-type peptidase activity.

2025年1月4日 · The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity.

Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. [3][4][5] The protein is a cysteine cathepsin, a lysosomal cysteine protease that plays a major role in intracellular protein catabolism. [6][7][8][9]

2021年3月27日 · Cathepsin L (CTSL), a member of the lysosomal cysteine protease, contains an L domain of α-helix and an R domain of β-sheet in the spatial structure. 15 Its main function is...

Results suggest the potential utility of cathepsin L (CTSL) in predicting the outcome of pediatric acute myeloid leukemia (AML). the findings demonstrated that mutated K-ras promotes cathepsin L expression and plays a pivotal role in EMT of human lung cancer.

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil Elastase activity.

2024年11月5日 · This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and …

这个基因编码的蛋白质是一种溶酶体半胱氨酸蛋白酶，在细胞内蛋白质分解代谢中扮演主要角色。 其底物包括胶原和弹性蛋白，以及α-1蛋白酶抑制剂，这是中性粒细胞弹性酶活性的主要调控因素。 该编码蛋白质与几种病理过程有关，包括肌纤维坏死、肌炎和心肌缺血，以及肾小管对蛋白尿的反应。 这种蛋白质是肽酶C1家族的成员，是一个由二硫键连接的重链和轻链组成的二聚体，两者都由单个蛋白质前体产生。 此外，该蛋白质切割SARS-CoV-2刺突蛋白的S1亚基，这是病毒进 …

2016年9月14日 · The protein encoded by the CTSL gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity.

Long isoform of CD74/Ii chain stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of APCs. IFNG enhances the conversion into the CTSL mature and active form (By similarity). Inhibited by CST6.