Sequential enzyme-activated macrotheranostic probe for selective …
2021年11月1日 · In summary, we present a new strategy for mitochondria-targeted macrotheranostic probes that can be sequentially activated by cancer cells overexpressing the …
Cathepsin L upregulation-induced EMT phenotype is associated …
2016年11月14日 · In the present study, we demonstrated that CTSL is a regulator of drug resistance in A549 cells, and the regulation of chemoresistance by CTSL is mediated through …
Selective cancer targeting with prodrugs activated by histone ...
2013年11月5日 · In this report, we describe a novel prodrug strategy targeting increased HDAC and CTSL activities in malignant tumours. In vitro proof-of-concept studies show that the …
Cathepsin L targeting in cancer treatment - PMC - PubMed …
Proteolytic enzymes may serve as promising targets for novel therapeutic treatment strategies seeking to impede cancer progression and metastasis. One such enzyme is cathepsin L …
Recent advances in HDAC-targeted imaging probes for
2022年9月1日 · In this work, we summarize recent progress of HDAC-targeted probes for cancer imaging and image-guided surgery, including bioluminescent probes, fluorescence probes and …
Cathepsin L targeting in cancer treatment - ScienceDirect
2015年11月1日 · CTSL upregulation, a common occurrence in a variety of human cancers, has been widely correlated with metastatic aggressiveness and poor patient prognosis. In addition, …
用于选择性肿瘤线粒体靶向的序列酶激活宏治疗探针,Acta …
基于共轭 CyNH 2 的 宏观治疗探针（表示为 PLCy） 带有乙酰化赖氨酸基团的荧光素和细胞毒性可通过癌细胞过度表达组蛋白去乙酰化酶 (HDAC) 和组织蛋白酶 L (CTSL) 的顺序激活而被揭 …
In this report, we describe a novel prodrug strategy targeting increased HDAC and CTSL activities in malignant tumours. In vitro proof-of-concept studies show that the prodrug exerts promising...
Cathepsin L upregulation-induced EMT phenotype is associated …
2016年11月14日 · Cathepsin L (CTSL), a lysosomal acid cysteine protease, is known to play important roles in tumor metastasis and chemotherapy resistance. In this study we …
An AND-gate bioluminescent probe for precise tumor imaging
2023年2月1日 · When the probe FK-Luc-BH enters tumor cells that co-express cathepsin L (CTSL) and ClO −, both peptide FK and benzoylhydrazine are removed to yield NH 2-Luc, …