2015年11月24日 · Within the network, certain proteases such as cathepsin B (CTSB) and CTSL represent highly integrated nodes whereas others, such as CTSH, CTSK or CTSZ, represent more discrete activities.

2010年1月21日 · We demonstrate that Ctsb and Ctsz single deficiencies have only marginal effects on most parameters of breast cancer development in this model, but that combined deficiency of Ctsb and Ctsz results in a significantly reduced tumor and metastatic burden of PymT-induced breast cancer in mice.

2024年5月22日 · To address a possible common role of highly expressed and functional important CTS proteases, we generated CTSB-, CTSD-, CTSL-, and CTSBDL-triple deficient (KO) human neuroblastoma-derived SH-SY5Y cells and CTSB-, CTSD-, CTSL-, CTSZ and CTSBDLZ-quadruple deficient (KO) HeLa cells.

2015年3月23日 · First, we demonstrate that GB111-NH 2 is a powerful and potent inhibitor of cathepsin B (CtsB), cathepsin L (CtsL) and cathepsin S (CtsS) in primary macrophages. Inhibition of macrophage...

溶酶体半胱氨酸蛋白酶组织蛋白酶 B (Ctsb) 和组织蛋白酶 Z (Ctsz，也称为组织蛋白酶 X/P) 与癌症发病机制有关。 已经建议在 Ctsb (-/-) 小鼠中通过 Ctsz 补偿 Ctsb。

组织蛋白酶B（CTSB） 是溶酶体内半胱氨酸蛋白水解酶，其催化作用由Cys ，His 实现，易被巯基试剂抑制，又称巯基酶，属于木瓜蛋白酶家族，在pH 3.0 ～ 7.0 都具有活性， 碱性条件下会不可逆失活 [3]。

2010年2月9日 · The lysosomal cysteine proteases cathepsin B (Ctsb) and cathepsin Z (Ctsz, also called cathepsin X/P) have been implicated in cancer pathogenesis. Compensation of Ctsb by Ctsz in Ctsb (-/-) mice has been suggested. To further define the functional interplay of these proteases in the context of cance …

该基因编码的蛋白质是一种溶酶体半胱氨酸蛋白酶，是肽酶 C1 家族的成员。 它表现出羧基单肽酶和羧基二肽酶活性。 编码的蛋白质也被称为组织蛋白酶 X 和组织蛋白酶 P。 该基因在癌细胞系和原发性肿瘤中普遍表达，并且与该家族的其他成员一样，可能参与肿瘤发生。 [RefSeq 提供，2008 年 10 月] The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities.

2016年1月15日 · Here we demonstrate stage-dependent effects of simultaneously deleting cathepsin B (CtsB) and CtsS in a murine pancreatic neuroendocrine tumor model. Early in tumorigenesis, the double knockout results in an additive reduction in angiogenic switching, whereas at late stages, several tumorigenic phenotypes are unexpectedly restored to wild-type ...

2024年12月24日 · CTSZ (Cathepsin Z) is a Protein Coding gene. Diseases associated with CTSZ include Cercarial Dermatitis and Rosacea. Among its related pathways are Transport to the Golgi and subsequent modification and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cysteine-type peptidase activity.