Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information.

2016年9月23日 · Here we report the solution structure of the Cuz1 AN1 ZnF which reveals a compact C6H2 zinc-coordinating domain that resembles a two-finger hand holding a tri-helical clamp. A central phenylalanine residue sits between the two zinc-coordinating centers.

2013年11月22日 · Cuz1, like its human ortholog ZFAND1, has both an AN1-type zinc finger (Zf_AN1) and a divergent ubiquitin-like domain (UBL). We show that Cuz1 modulates Cdc48 function in the UPS. The two proteins directly interact, and the Cuz1 UBL, but not Zf_AN1, is necessary for binding to the Cdc48 N-terminal domain.

2014年1月1日 · Cuz1/Ynl155w functions as a zinc-dependent ubiquitin-binding protein. Thus, Cuz1/Ynl155w is proposed to protect cells from metalloid-induced proteotoxicity by delivering ubiquitinated substrates to Cdc48 and the proteasome for destruction.

Here we report the solution structure of the Cuz1 AN1 ZnF which reveals a compact C6H2 zinc-coordinating domain that resembles a two-finger hand holding a tri-helical clamp. A central phenylala-nine residue sits between the two zinc-coordinating centers.

Cuz1是酿酒酵母中两个AN1 ZnF蛋白之一，并且是一种应激诱导型蛋白，通过与蛋白酶体和Cdc48的直接相互作用而在蛋白降解中起作用。 在这里，我们报告的Cuz1 AN1 ZnF的解决方案结构，揭示了一个紧凑的C6H2锌配位域，类似于两个手指的手，握着三螺旋夹。

2014年1月17日 · Cuz1/Ynl155w functions as a zinc-dependent ubiquitin-binding protein. Thus, Cuz1/Ynl155w is proposed to protect cells from metalloid-induced proteotoxicity by delivering ubiquitinated substrates to Cdc48 and the proteasome for destruction.

SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. The yeast GO Slim terms are higher level terms that best represent the major S. cerevisiae biological processes, functions, and …

2016年9月23日 · Here we report the solution structure of the Cuz1 AN1 ZnF which reveals a compact C6H2 zinc-coordinating domain that resembles a two-finger hand holding a tri-helical clamp. A central phenylalanine residue sits between the two zinc-coordinating centers.

CUZ1 / YNL155W Sequence Sequences and genome annotation information for Reference Strain S288C and a select set of Alternative References.