Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes .

2024年12月24日 · CXCL6 (C-X-C Motif Chemokine Ligand 6) is a Protein Coding gene. Diseases associated with CXCL6 include Tonsillitis and Intracranial Arteriosclerosis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and GPCR downstream signalling.

下游通路研究发现，一方面自分泌CXCL6通过上调 E2F1 表达进而促进下游SOX2, NANOG, MYC等基因表达促进HCC干性，另一方面自分泌TGF-β通过 p38 通路参与HCC干性维持。 STAT3-CXCL6/TGF-β通路是CLCF1介导的HCC细胞干性的部分原因. 那HCC细胞中发生的变化是否对周围免疫细胞有影响呢，作者进一步发现HCC中增加的CXCL6和TGF-β以旁分泌方式分别 招募中性粒细胞以及促进其“促肿瘤”的N2极化。 CLCF1诱导HCC细胞分泌的CXCL6和TGF-β协同诱导中 …

CXCL6 exerts neutrophil-activating and angiogenic activities, and has antibacterial action against Gram-negative and Gram-positive bacteria. CXCL6 is an ELR-positive CXC chemokine with a length of 77 amino acids.

2023年7月1日 · CXCL6, also known as granulocyte chemotactic protein 2, is a chemoattractant for neutrophils through receptors CXCR1 and CXCR2. It is closely related to cell permeability, apoptosis...

CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation. CXCL6 fuels the growth and metastases of esophageal squamous cell carcinoma cells both in vitro and in vivo through upregulation of PD-L1 via activation of STAT3 pathway.

2021年1月2日 · Chemokine (C-X-C motif) ligand 6 (CXCL6), a member of the CXC chemokine family, reportedly mediates several processes such as inflammation, immunoreaction, cell growth, and metastasis through interaction with the chemokine receptors CXCR1 and CXCR2 in humans; further, CXCR1 and CXCR2 can promote rep …

CXCL6, also known as granulocyte chemoattractant protein-2 (GCP-2), can recruit neutrophils to complete non-specific immunity in the process of inflammation. Cancer-related genes and interleukin family can promote the abnormal secretion of CXCL6, which promotes tumor growth, metastasis, epithelial mesenchymal transformation (EMT) and ...

CXCL6又称为粒细胞趋化蛋白-2（GCP-2），在炎症过程中可以招募中性粒细胞完成非特异性免疫。 癌症相关基因和白细胞介素家族可以促进CXCL6的异常分泌，从而促进TME中的肿瘤生长、转移、上皮间质转化（EMT）和血管生成。 CXCL6还具有促进纤维化和组织损伤修复的作用。 本篇综述，我们基于TME重点关注影响CXCL6表达的调控网络、其在炎症进展中的作用以及其如何影响肿瘤的发生和进展，试图为炎症和疾病等疾病的治疗提供潜在靶点。 癌症。 Chemokines …

2025年1月4日 · Title: CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation. CXCL6 fuels the growth and metastases of esophageal squamous cell carcinoma cells both in vitro and in vivo through upregulation of PD-L1 via activation of STAT3 pathway.