2018年1月2日 · Through a series of crystal structures of CXXC domains with DNA ligands, we unravel the molecular mechanisms of how these CXXC domains, including single CXXC …

CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded …

2018年1月2日 · Here we systematically measured and compared the DNA-binding selectivities of all known human CXXC domains by different binding assays, and complemented the existing …

2021年8月2日 · CXXC5 is a member of the zinc-finger CXXC family that binds to unmethylated CpG dinucleotides. CXXC5 modulates gene expressions resulting in diverse cellular events …

2016年5月23日 · CXXC finger protein 1 (Cxxc1) is defined as an unmethylated CpG-binding protein regulating DNA methylation through its DNA-binding domain. It is also a component of …

2020年3月17日 · The most significant feature of meiosis is the recombination process during prophase I. CXXC finger protein 1 (CXXC1) binds to CpG islands and mediates the deposition …

Recently, a family of proteins which encode a ZF-CxxC (zinc finger-CxxC) domain have been shown to specifically recognize non-methylated DNA and recruit chromatin-modifying activities …

CXXC5基因是视色素反应基因,编码视色素诱导的核因子,又可称为RINF。 CXXC5除了作为表观遗传调控因子外,还可以通过调控Wnt/β-catenin 通路参与细胞的生长和分化过程;CXXC5 多种恶 …

2020年3月13日 · In this review, we summarize these human CXXC domain-containing proteins in terms of their structures, biology, and biochemistry, and also discuss how they mediate cross …

CXXC5 is a member of the CXXC-type zinc-finger protein family. Proteins in this family play a pivotal role in epigenetic regulation by binding to unmethylated CpG islands in gene promoters …