2024年12月24日 · CYB5B (Cytochrome B5 Type B) is a Protein Coding gene. Diseases associated with CYB5B include Alzheimer Disease 13 and Robinow Syndrome, Autosomal Dominant 2. Among its related pathways are Oxidation by cytochrome P450 and …

Title: Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B). could be involved in the differential modulation of 17 alpha-hydroxylase and 17,20-lyase activities of P450c17 [type2 cyt-b5]

2025年2月9日 · Gene ID: 80777, updated on 9-Feb-2025. Enables heme binding activity. Contributes to nitrite reductase (NO-forming) activity. Involved in nitric oxide biosynthetic process. Located in membrane. Part of nitric-oxide synthase complex. [provided by Alliance of Genome Resources, Feb 2025]

2024年11月26日 · Cytochrome b5 (CYB5) is a hemoprotein crucial for electron transfer to oxygenases. Ma et al. show that CYB5A and CYB5B functionally compensate for sterol C4-demethylation in cholesterol biosynthesis. Depletion of CYB5A and CYB5B causes the accumulation of SC4MOL substrates T-MAS and dihydro-T-MAS, which inhibit the SREBP pathway and activate ...

2024年1月7日 · Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B). Murphy D, Parker J, Zhou M, Fadlelmola FM, Steidl C, Karsan A, Gascoyne RD, Chen H, Banerjee DMurphy D, et al .

This gene has 17 transcripts (splice variants), 224 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 70.4), colon (RPKM 17.6) and 22 other tissues.

CYB5B is a prognostic marker in Head and neck squamous cell carcinoma, Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma

Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

CYB5B had 17,20-lyase activity as measured by the conversion of pregnenolone to dehydroepiandrosterone (DHEA) when expressed in HEK293 cells. Mapping Hartz (2010) mapped the CYB5B gene to chromosome 16q22.1 based on an alignment of the CYB5B sequence (GenBank AB009282) with the genomic sequence (GRCh37).

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Lineage-specific biology revealed by a finished genome assembly of the mouse.