Suivez vos comptes à tout moment depuis votre mobile, tablette, PC ou même votre montre connectée, en toute simplicité. Éditez facilement un RIB, retrouvez nos Caisses et distributeurs à proximité... Disponible pour smartphone et tablette iOS et Android. Vous bénéficiez d'un conseiller dédié. Il privilégie vos intérêts car il connait vos besoins.

CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria …

Therefore, our results identify a Zeb1-microRNA-96/182-Cybb pathway that controls cross-presentation in cDC1 and uncover an essential role of Zeb1 in cDC1 homeostasis. Dendritic cells play a...

Connectez-vous à votre Espace Client du Crédit Mutuel à l'aide de votre identifiant et mot de passe.

性联 隐性遗传 的慢性肉芽肿病的各亚型均是由于编码细胞色素b的qp91-phox亚单位基因突变引起，该基因被命名为 CYBB (MIM306400)，含有13个 外显子，位于X染色体xp21.1，约占30kb。 根据多 中心国际 数据库对261例性联CGD患儿的 分析结果，该基因突变存在明显的 异质性，多有家族特异性。 基因缺失、 错义突变 和无意义突变 发生率 接近分别占全部突变的20%，剪切为点突变 (16%)和插入 (10%)，则占剩余突变的大部分。 目前还发现存在两种调节突变CyBB基因突变 …

2023年11月3日 · facilitated its survival by inducing CYBB-mediated macrophage ferroptosis leading to its alternative activation and might reveal the potential for a new therapeutic strategy of leprosy.

2018年9月11日 · Genetic analysis revealed a de novo mutation in exon 5 of the CYBB gene: a single-nucleotide substitution, c.376T > C, leading to a C126R change. Keywords: chronic granulomatous disease (CGD), NADPH oxidase, CYBB gene, novel mutation, pneumonia.

Herein, we demonstrated that a subunit of NADPH oxidase, CYBB, orchestrated mesenchymal shift and promoted TMZ resistance by modulating the anti-ferroptosis circuitry Nrf2/SOD2 axis. Public transcriptomic data re-analysis found that CYBB and SOD2 were highly upregulated in the mesenchymal subtype of GBM.

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain.It has been proposed as a primary component of the microbicidal oxidase system of phagocytes.CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD).In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to ...

Here we show that CybB from E. coli functions as a superoxide:ubiquinone oxidoreductase, performing a previously undescribed enzymatic reaction in which superoxide is directly oxidized to molecular oxygen and the sequestered electron is funneled to ubiquinone. The protein thus functions as a superoxide oxidase (SOO).