NADPH oxidase 2 (Nox2), also known as cytochrome b (558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2 gene (also called CYBB gene). [5] . The protein is a superoxide generating enzyme which forms reactive oxygen species (ROS). The CYBB gene encode cytochrome b-245, beta chain.

补偿性抗氧化剂 SOD2 基本上可以防止高 ROS 的有害影响，同时减弱 TMZ 抗性细胞的铁死亡。一项动物研究强调了 SOD2 在减轻 erastin 触发的铁死亡和耐受 TMZ 抗性 GBM 细胞异种移植小鼠的氧化应激负担方面的保护作用。因此，CYBB 捕获了间充质 GBM 中的铁死亡弹性。

2020年4月13日 · To identify differentially expressed ROS and antigen-presenting genes in single-cell clusters, we compared expression of the pro-oxidant gene Cybb, which encodes the nicotinamide adenine ...

2020年5月13日 · Here, we report that the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2, also known as CYBB/NOX2, in conventional DCs (cDCs) regulates endocytosed MOG (myelin oligodendrocyte protein) antigen processing and supports MOG-antigen presentation to CD4 + T cells through LC3-associated phagocytosis (LAP).

2024年4月30日 · The activation of CYBB results in the accumulation of reactive oxygen species (ROS) and contributes to the development of drug-resistant phenotypes in acute myeloid leukemia (AML) [37]. We investigated the potential value of CYBB in glioma using data from glioma patients in the CGGA and TCGA databases.

2023年4月22日 · An in vitro study demonstrated that TMZ-resistant GBM cells displayed mesenchymal and stemness features while remaining resilient to erastin-mediated ferroptosis by activating the CYBB/Nrf2/SOD2 axis. The CYBB maintained a high ROS state to sustain the mesenchymal phenotype, TMZ resistance, and reduced erastin sensitivity.

Platelet ROS are mostly generated by reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. NOX2 is an isoform from NADPH oxidase expressed in platelets and an important regulator of platelet activation-associated thrombosis.

2018年12月7日 · We identified cytochrome b-245 heavy chain (CYBB), a gene encoding a reactive oxygen species (ROS)-generating enzyme, to be important for human M1 macrophage polarization, which supports previous findings of oxidative stress as a critical regulator of macrophage function.

该研究表明NADPH氧化酶的亚单位CYBB通过调节抗铁死亡的Nrf2 / SOD2轴，协调间质转化并促进TMZ抵抗。 研究发现，CYBB和SOD2在GBM的间质亚型中高度上调。 在体内研究中，TMZ耐药的GBM细胞表现出间质和干细胞特征，同时通过激活CYBB / Nrf2 / SOD2轴来保持高ROS状态，维持间质表型，TMZ抵抗和降低铁死亡敏感性。 机械上，CYBB与Nrf2相互作用，从而调节SOD2转录。 SOD2的代偿性抗氧化剂本质上保护免受高ROS的有害影响，同时减轻了TMZ耐药细胞 …

2022年5月18日 · Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In humans, a lack of ROS causes chronic and extreme bacterial infections, while...