Regulated repression governs the cell fate promoter ... - Nature
2020年5月8日 · Our data demonstrate that the promoter of a master regulator is primed for rapid activation while repression by multiple TFs mediating Tup1-Cyc8 recruitment dictates the fate …
Cloning and characterization of the CYC8 gene mediating glucose ...
1988年12月15日 · Mutations m the CYC 8 ( = SSN 6) gene of Saccharomyces cerevisiae alleviate glucose repression of many glucose-repressible genes. The gene was isolated by screening …
Functional characterization and comparative analysis of gene
2023年3月1日 · Transcriptional corepressors Sin3, Cyc8 and Tup1 are important for downregulation of gene expression by recruiting various histone deacetylases once they gain …
Cyc8p and Tup1p transcription regulators antagonistically regulate ...
2018年7月2日 · The decreased level of CYC8 mRNA and level of Cyc8p in this p GAL - CYC8 strain (grown without galactose), compared with the BR-F strain, was confirmed by northern …
Dynamic Sumoylation of a Conserved Transcription Corepressor …
2016年1月22日 · We propose that sumoylation protects against persistent inclusion formation during hyperosmotic stress, allowing optimal transcriptional function of the Cyc8-Tup1 …
The Cyc8-Tup1 complex inhibits transcription primarily by masking …
2011年12月1日 · The yeast Tup1-Cyc8 corepressor complex is recruited to promoters by DNA-binding repressors, but the mechanisms by which it inhibits expression of genes involved in …
The yeast global transcriptional co-repressor protein Cyc8 can
2009年2月15日 · Cyc8, a co-repressor that regulates a similar set of genes as SWI, also propagates as a prion, suggesting a link between chromatin remodelling and cytoplasmic …
The Tup1-Cyc8 Protein Complex Can Shift from a Transcriptional Co ...
1999年1月1日 · Cyc8 (Ssn6)-Tup1, a general co-repressor complex, is recruited to promoter DNA via interactions with DNA-binding regulatory proteins and inhibits the transcription of many …
The yeast Cyc8–Tup1 complex cooperates with Hda1p and Rpd3p …
2014年11月1日 · The yeast histone deacetylases, Hda1p and Rpd3p, occupy the repressed FLO1 promoter region in a Cyc8–Tup1 dependent manner and coordinate histone deacetylation, …
852410 - Gene ResultCYC8 transcription regulator CYC8 []
Transcriptional repressor Gal80 recruits corepressor complex Cyc8-Tup1 to structural genes of the Saccharomyces cerevisiae GAL regulon. Functional analysis of Cti6 core domain …