Arginylglycylaspartic acid (RGD) is the most common peptide motif responsible for cell adhesion to the extracellular matrix (ECM), found in species ranging from Drosophila to humans.

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and …

Radiolabeled cyclic RGD peptides represent a new class of radiotracers for diagnosis of tumor or thrombosis, depending upon their selectivity for α v β 3 or α IIb β 3.

2015年7月20日 · This article will use the dimeric and tetrameric cyclic RGD peptides developed in our laboratories as examples to illustrate basic principles for development of α v β 3-targeted radiotracers. It will focus on different approaches to maximize the radiotracer tumor uptake and tumor/background ratios.

2018年4月1日 · In this study, the cyclic RGD (cRGD) functionalized liposomes were prepared to encapsulate urokinase, a cheap and widely used thrombolytic drug in clinic and better thrombolysis efficacy was achieved. The flow cytometry analysis showed that the cRGD liposomes could bind to the activated platelets while not to the resting platelets.

2016年4月12日 · This article will use the multimeric cyclic RGD peptides as examples to illustrate basic principles for development of integrin-targeted radiotracers and focus on different approaches to maximize their tumor uptake and T/B ratios. It will also discuss important assays for pre-clinical evaluations of the integrin-targeted radiotracers, and their ...

2024年2月21日 · To this end, we propose a pioneering boron-infused cyclic Arg-Gly-Asp (RGD) peptide, cRGD (d -BPA)K, designed as an efficacious BNCT tracer. Additionally, we introduce its diagnostic complement, DOTA-cRGD (d -BPA)K, tailored for positron emission tomography (PET) to visualize α v β 3 expressed tumors.

2013年9月12日 · We here achieved highly efficient drug delivery to U87MG tumors by using a platinum anticancer drug-incorporating polymeric micelle (PM) with cyclic Arg-Gly-Asp (cRGD) ligand molecules.

2025年3月14日 · RGD-containing peptides have various applications, including cancer treatment, tissue engineering, drug delivery, and imaging. The potent RGD-containing peptides cilengitide (cRGDfMeV) and iRGD (cCRGDKGDPC) show strong αvβ3- and αvβ5-binding activity; however, their therapeutic action is mediated by integrin αvβ5 rather than αvβ3.

2012年2月29日 · In summary, we accomplished the efficient solid-phase synthesis of cyclic RGD peptides by utilizing COMU under controlled MW heating. We demonstrate that the use of COMU is effective for the coupling of Fmoc-Arg(Pbf)-OH under MW irradiation at 50 °C for 10 min.