Cyclin E is a member of the cyclin family. Cyclin E binds to G 1 phase Cdk2, which is required for the transition from G 1 to S phase of the cell cycle that determines initiation of DNA duplication.

Cyclin E overexpression not only accelerates the proliferation and division of tumor cells by promoting cell cycle transformation but also induces the expression of related products, …

2021年11月24日 · Cyclin E/CDK2 complex mostly controls cell cycle progression and DNA replication through phosphorylation of specific substrates. Oncogenic activation of Cyclin …

Recent reports demonstrate that inappropriate cyclin E expression may have far-reaching biological consequences for cell physiology, including altering gene expression programs …

Cyclin E binds and activates the kinase Cdk2 and by phosphorylating its substrates, the so-called "pocket proteins", the cyclic/Cdk2 complexes initiate a cascade of events that leads to the …

2021年5月27日 · E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin …

E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent …

Cyclin E is a protein that plays a crucial role in cell-cycle regulation by facilitating centrosome replication and allowing premature entry of cells into the S phase. It is often associated with …

2005年4月18日 · In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells. Cyclin-dependent kinases control cell cycle transitions. These …

2004年8月1日 · Cyclin E binds and activates the kinase Cdk2 and by phosphorylating its substrates, the so-called “pocket proteins”, the cyclic/Cdk2 complexes initiate a cascade of …