Cyclopamine (11-deoxojervine) is a naturally occurring steroidal alkaloid. It is a teratogenic component of corn lily (Veratrum californicum), which when consumed during gestation has …

The cyclopic phenotype of Shh knockout mice led us to identify the teratogenic plant compound cyclopamine as a specific antagonist of Hh pathway activity, and to show that cyclopamine …

By inhibiting the sonic hedgehog pathway in mice with a controlled dose of cyclopamine, scientists hope to find a way to combat potentially deadly tumors in humans.

Treatment with small molecule Hh inhibitors such as HhAntag and the natural product Cyclopamine, both binding to Smo, induces tumor remission in a genetic mouse model of …

Cyclopamine consists of a hexacyclic framework of four annulated carbocycles, three of them are six-membered rings (A, B, and D ring) and one is a five-membered ring (C ring).

2011年1月1日 · Jervine and cyclopamine were two important teratogenic compounds isolated from Veratrum californicum (Fig. 12.1, compound 2 and 6, respectively), while numerous …

2014年4月10日 · Cyclopamine was found to inhibit the hedgehog (Hh) signaling pathway, which plays a critical role in embryonic development. More recently, aberrant Hh signaling has been …

Cyclopamine is a naturally occurring steroidal alkaloid that attenuates the Hedgehog signaling pathway by inhibiting the Smoothened receptor. The Hedgehog pathway plays an important …

Cyclopamine (C9710) is a steroidal alkaloid isolated from the corn lily (Veratrum californicum) known for its inhibitory action on Hedgehog (Hh) signaling pathways. Across a variety of …