2024年12月24日 · CYP11A1 (Cytochrome P450 Family 11 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP11A1 include Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal, Partial Or Complete and Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11a1 Deficiency.

P450scc is a member of the cytochrome P450 superfamily of enzymes (family 11, subfamily A, polypeptide 1) and is encoded by the CYP11A1 gene. [6] The systematic name of this enzyme class is cholesterol, reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving). Other names include: steroid 20-22-lyase.

胆固醇侧链裂解酶 （英語： Cholesterol side-chain cleavage enzyme， CYP11A1 或 P450scc，其中“scc”是“ s ide- c hain 侧链 ”“ c leavage 裂解 ”的缩写）是一种将 胆固醇 转化为 孕烯醇酮 的 线粒体 酶。 这是所有 哺乳动物 中由胆固醇生成各种 甾类激素 的第一步反应 [7]。 P450scc 是 细胞色素P450 氧化酶超家族的一员（家族11亚家族A多肽1）， 基因 名为 CYP11A1[8]。 ^ 與胆固醇侧链裂解酶相關的疾病；在維基數據上查看/編輯參考. ^ 對胆固醇侧 …

细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。 这种蛋白质定位于线粒体内膜并催化胆固醇转化为孕烯醇酮，这是类固醇激素合成中的第一步和限速步骤。 已发现该基因的两个转录本变体编码不同的亚型。 较小同种型的细胞定位尚不清楚，因为它缺乏靶向线粒体的转运肽。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the Cytochrome P450 superfamily of Enzymes.

Expression and activation of the steroidogenic enzyme CYP11A1 is associated with IL-13 production in T cells from peanut allergic children. Our findings indicated that rs28681535 in CYP11A1 might be protective factors for ischemic stroke, while CYP11A1 rs12912592 polymorphism be a risk factor for ischemic stroke in Chinese Han population.

2025年2月8日 · Clinical resource with information about CYP11A1, Congenital adrenal insufficiency with 46, XY sex reversal OR 46,XY disorder of sex development-adrenal insufficiency due to CYP11A1 deficiency, and available tests.

CYP11A1, also known as cytochrome P450 side chain cleavage (P450scc), is a mitochondrial enzyme best characterized for its catalysis of the cleavage of the side chain of cholesterol to produce pregnenolone, the common precursor of steroid hormones [1, 2].

2022年12月2日 · Binding of steroid hormones to their cognate receptors regulates the growth of most prostate and breast cancers. We hypothesized that CYP11A inhibition might halt the synthesis of all steroid hormones, because CYP11A is the only enzyme that catalyses the first step of steroid hormone biosynthesis.

2025年2月8日 · Placenta-specific CYP11A1 overexpression lead to autism-like symptom in offspring with altered steroid hormone biosynthesis in the placenta-brain axis and rescued by vitamin D intervention. FXR Maintains the Intestinal Barrier and Stemness by Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction Diseases.

这个蛋白定位在线粒体内膜上，催化胆固醇向孕烯醇酮的转化，这是类固醇激素合成的第一步和限速步骤。 已经发现这个基因的两个转录变异体，编码不同的异构体。 较小的异构体的细胞定位尚不清楚，因为它缺乏线粒体靶向的转运肽。 [RefSeq，2008年7月提供] Dir./Indir. Analysis of the DNA sequence and duplication history of human chromosome 15. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.