Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. [5] CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein).

Cysteine-rich 61 (Cyr61, also called CCN1), a novel secreted matricellular protein, is encoded by a growth factor-inducible immediate-early gene. Cyr61 expression is at low levels in most adult tissues under homeostatic conditions, and remarkably elevated with the induction of cytokines and growth factors . Numerous studies have revealed that ...

CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein that plays essential roles in cardiovascular development during embryogenesis, and regulates inflammation, wound healing and fibrogenesis in the adult.

近年研究发现，富含半胱氨酸蛋白61(cysteine-rich 61，Cyr61)在多种肿瘤中异常表达并通过与整联蛋白相结合，促进肿瘤细胞的增殖、增强其侵袭性与抗凋亡能力、参与肿瘤血管生成和肿瘤转移，并与肿瘤的恶性程度、转移以及预后密切相关，现认为Cyr61可能是一种新 ...

2023年9月27日 · Mooring et al. show that the protein cysteine-rich angiogenic inducer 61 (CYR61) promotes liver-infiltrating macrophage polarization in NASH, leading to inflammation and fibrosis via NF-κB–linked and PDGFa/b-linked signaling pathways, respectively. The authors also developed a CYR61-blocking antibody that ameliorated inflammatory and ...

CYR61 (CCN1) is a member of the CCN family of secreted matricellular proteins that functions as a ligand of integrin receptors and BMPs. Cyr61 invalidation shows that this factor is essential for placental development and vascular integrity [50].

2022年10月1日 · We have selected the HCT116 Sh3 CyR61 cell line with the strongest CyR61 downregulation and performed an IncuCyte Scratch Wound Assay and an IncuCyte Cell Count Proliferation Assay. CyR61 silencing produced a slight, but statistically significant suppression of cell proliferation.

Cyr61 (cysteine-rich 61)是结缔组织生长因子 (CCN)家族成员之一,是富含半胱氨酸的分泌性肝素连接蛋白.最初认为是生长因子诱导的即刻早期基因产物,其编码蛋白具有明显的促有丝分裂原性和趋化性,能刺激细胞增殖,趋化,粘附和促进细胞外基质形成.在动脉粥样硬化,血管再狭窄以及肿瘤形成等多种生物学过程中起着重要作用. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的学术服务。 在这里我们保持学习的态度，不忘初 …

2014年3月18日 · Cystein-rich protein 61 (CYR61/CCN1) is a component of the extracellular matrix, which is produced and secreted by several cell types including endothelial cells, fibroblasts and smooth muscle cells. CCN1 has been implicated in leukocyte migration and the inflammatory process, but it is also involved in cardiovascular development and ...

2013年3月22日 · In this work, we performed a screen for modifiers of dendritic growth in hippocampal neurons, the expression of which is potentially regulated by mTOR. As a result, we identified Cyr61, an angiogenic factor with unknown neuronal function, as a novel regulator of dendritic growth, which controls dendritic growth in a β1-integrin-dependent manner.