
Structural analysis of cytochrome bc1 complexes: Implications to …
2013年11月1日 · Ubiquinol cytochrome c oxidoreductase, commonly referred to as complex III or the cytochrome bc1 complex (cyt bc1 or bc1), is a multifunctional, oligomeric membrane protein complex localized to the inner mitochondrial membrane of eukaryotes or the cytoplasmic membrane of prokaryotic organisms.
The cytochrome bc1 complex: function in the context of structure
The bc1 complexes are intrinsic membrane proteins that catalyze the oxidation of ubihydroquinone and the reduction of cytochrome c in mitochondrial respiratory chains and bacterial photosynthetic and respiratory chains. The bc1 complex operates through a Q-cycle mechanism that couples electron trans …
Biogenesis of the cytochrome bc1 complex and role of …
2012年2月1日 · Ubiquinol–cytochrome c oxidoreductase (E.C. 1.10.2.2, cytochrome bc1 complex, Complex III) is a central component of the respiratory electron transport chain embedded in the inner membrane of mitochondria in eukaryotes.
Ubiquinol-Cytochrome c Oxidoreductase (Complex III)
Ubiquinol-cytochrome c oxidoreductase, commonly referred to as complex III or the cytochrome bc 1 complex, is a multifunctional, oligomeric membrane protein complex localized to the inner mitochondrial membrane of eukaryotic cells or the cytoplasmic …
Mitochondrial Cytochrome bc1 Complex as Validated Drug …
Mitochondrial respiratory chain Complex III, also known as cytochrome bc1 complex or cyt bc1, is a validated target not only for antibiotics but also for pesticides and anti-parasitic drugs.
Crystal structure of bacterial cytochrome bc1 in complex with ...
2019年8月9日 · Cytochrome bc1 complexes (cyt bc1), also known as complex III in mitochondria, are components of the cellular respiratory chain and of the photosynthetic apparatus of non-oxygenic photosynthetic bacteria.
The cytochrome bc1 complex as an antipathogenic target
2020年6月23日 · The cytochrome bc 1 complex (respiratory complex III, Cyt bc 1, EC: 1.10.2.2) of eukaryotic mitochondrial and prokaryotic energy-transducing membranes is a proven target for antimicrobial agents of medical and agricultural interest [[1-7]].
Structural analysis of atovaquone-inhibited cytochrome bc1
2014年6月4日 · Here we describe the X-ray structure of mitochondrial cyt bc1 from Saccharomyces cerevisiae with atovaquone bound in the catalytic Qo site, at 3.0-Å resolution. A polarized H-bond to His181 of...
Structural Analysis of Cytochrome bc1 Complexes: Implications to …
2021年11月13日 · Ubiquinol cytochrome c oxidoreductase, commonly referred to as complex III or the cytochrome bc1 complex (cyt bc1 or bc1), is a multifunctional, oligomeric membrane protein complex localized to the inner mitochondrial membrane of eukaryotes or the cytoplasmic membrane of prokaryotic organisms.
Cryo-EM structures of engineered active bc1-cbb3 type CIII2CIV …
2021年2月10日 · Here, we report the structure of an engineered bc1 - cbb3 type SC (CIII 2 CIV, 5.2 Å resolution) and three conformers of native CIII 2 (3.3 Å resolution). The SC is active in vivo and in vitro,...