D-SPIN identifies a set of gene programs that coexpress in the data, and represent each cell as a combination of gene program expression states. D-SPIN uses cross-correlation and mean of …

D-SPIN identifies a set of gene programs that coexpress in the data, and represent each cell as a combination of gene program expression states. D-SPIN uses cross-correlation and mean of …

Apr 21, 2023 · D-SPIN provides a computational framework for constructing interpretable models of gene-regulatory networks to reveal principles of cellular information processing and physiological control.

Here, we introduce a computational framework, D-SPIN, that generates quantitative models of gene regulatory networks from single-cell mRNA-seq datasets collected across thousands of distinct perturbation conditions.

Sep 17, 2019 · 各位老师同学，我看到一篇文献用自旋向下的d带的中心来描述催化剂对中间体的吸附活性，他的解释是自旋向下的d带中心相对费米能级更高，原话是“It is well known that spin ...,计算化学公社

Apr 21, 2023 · Using large perturb-seq and drug-response data sets, we demonstrate that D-SPIN models reveal the organization of cellular pathways, sub-functions of macromolecular complexes, and the logic of cellular regulation of transcription, translation, metabolism, and protein degradation in response to gene knock-down perturbations.

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Apr 19, 2023 · Using large Perturb-seq and drug-response datasets, we demonstrate that D-SPIN models reveal the organization of cellular pathways, sub-functions of macromolecular complexes, and the logic of cellular regulation of transcription, translation, metabolism, and protein degradation in response to gene knockdown perturbations.

Jun 4, 2024 · Using large Perturb-seq and drug-response datasets, we demonstrate that D-SPIN models reveal the organization of cellular pathways, sub-functions of macromolecular complexes, and the logic of cellular regulation of transcription, translation, metabolism, and protein degradation in response to gene knockdown perturbations.

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