D1R and D2R are the prototypical G s and G i coupled dopamine receptors and comparisons of the D1R and D2R structures provide the basis for the G protein coupling specificity. Three notable differences are observed at the cytoplasmic side between the active D1R and D2R structures.

We found that the pattern of activity of both D1R and D2R neurons in the DLS underwent marked changes during motor learning, with a gradual emergence of spatially dispersed neuronal ensembles that reproducibly fired in a sequential manner.

Dopamine signals mainly through D1 receptors (D1Rs) and D2 receptors (D2Rs); D1R-expressing or D2R-expressing neurons contribute to distinct reward and addictive behaviors.

2021年2月10日 · The dopamine G protein-coupled receptors — composed of the D1-like (including D1R and D5R) and D2-like receptors (including D2R, D3R, and D4R), which signal through the stimulatory G s...

2021年2月18日 · Here, we report four cryoelectron microscopy (cryo-EM) structures of D1R-G s and D2R-G i signaling complexes with selective and non-selective dopamine agonists, including two currently used anti-Parkinson's disease drugs, apomorphine and bromocriptine.

2024年7月4日 · We found that D1/D2-SPNs have a single projection pathway to the GPe, dissociating them from a direct pathway to the EPN/SNr. This mapping indicates that D1/D2-SPNs give rise to an additional...

Here, we address these questions by combining optogenetic activation of D1R and D2R cells in the mouse ventrolateral caudoputamen with fMRI. Striatal D1R/D2R stimulation evokes distinct activity within the BG-thalamocortical network and differentially engages cerebellar and …

2023年5月23日 · Here, we report the cryo-EM structures of all five dopamine receptors, D1R, D2R, D3R, D4R, and D5R, in complex with G proteins, among which the D4R and D5R structures are the first set of their...

2021年2月10日 · Here, we highlight significant differences between D1R- and D2R-MSNs subpopulations, such as morphology, electrophysiology, transcriptomic, functionality, and localization in the striatum. We discuss possible reasons for …

2021年2月18日 · 通过对D1R和D2R受体进行结构药理学研究并揭示其配体选择性的分子机制，对理解配体结合特性、受体激活和设计更高效的多巴胺受体靶向抗神经精神疾病类药物具有重要的科学意义和临床应用价值。 目前，尽管已有一些多巴胺受体亚型的结构获得解析，包括D2R、D3R和D4R与拮抗剂结合复合物的晶体结构以及D2R（突变型）与激动剂复合物的低分辨率冷冻电镜 …