2024年12月24日 · D2HGDH (D-2-Hydroxyglutarate Dehydrogenase) is a Protein Coding gene. Diseases associated with D2HGDH include D-2-Hydroxyglutaric Aciduria 1 and D-2-Hydroxyglutaric Aciduria. Among its related pathways are …

This gene encodes D-2hydroxyglutarate dehydrogenase is a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D …

2015年7月16日 · Here we show that wild-type D2HGDH elevates α-KG levels, influencing histone and DNA methylation, and HIF1α hydroxylation. Conversely, the D2HGDH mutants that we find in diffuse large B-cell...

hot和d2hgdh可能导致lps刺激的巨噬细胞中d-2hg升高. 2hg 水平可以通过特异性合成和降解两种对映异构体的各种酶进行调节，如图 2a 中 d-2hg 的示意图中详述。

2024年12月30日 · Downregulating D-2-hydroxyglutarate dehydrogenase (D2HGDH) increases epilepsy susceptibility by altering reactive oxygen species (ROS) levels and synaptic function, contributing to oxidative stress i...

该基因编码 D-2 羟基戊二酸脱氢酶，一种属于 FAD 结合氧化还原酶/转移酶 4 型家族的线粒体酶。 这种酶在肝脏和肾脏中最活跃，但在心脏和大脑中也很活跃，可将 D-2-羟基戊二酸转化为 2-酮戊二酸。 该基因的突变存在于 D-2-羟基戊二酸尿症中，这是一种罕见的隐性神经代谢障碍，可导致发育迟缓、癫痫、肌张力减退和畸形特征。 [RefSeq 提供，2008 年 7 月] This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial Enzyme belonging to the FAD-binding …

2025年1月4日 · D2HGDH elevates alpha-KG levels via IDH2 expression modulation, influencing histone and DNA methylation, and HIF1alpha hydroxylation. D2HGDH mutants found in diffuse large B-cell lymphoma are enzymatically inert.

2023年11月23日 · Clinical resource with information about D2HGDH, D-2-hydroxyglutaric aciduria 1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2022年3月2日 · D2HGDH is an inducible enzyme that converts D2HG into the endogenous metabolite 2-oxoglutarate. We aimed to evaluate the impairment of CD8 T lymphocyte function in the high-D2HG environment and to explore the phenotypic features and anti-tumor effect of D2HGDH-modified CAR-T cells.

The D2HGDH gene provides instructions for making an enzyme called D-2-hydroxyglutarate dehydrogenase. This enzyme is found in mitochondria, which are the energy-producing centers within cells.