DAF-16 is notable for being the primary transcription factor required for the profound lifespan extension observed upon mutation of the insulin-like receptor DAF-2. [5] The gene has played a large role in research into longevity and the insulin signalling pathway as it is located in C. elegans , a successful ageing model organism.

在 长寿 和衰老的研究中，科学家发现调控休眠态的幼虫形成的基因（daf基因）能影响 线虫 的长寿，其中daf-2、daf-16是作用于这一遗传调控通路下游的两个重要基因，其中daf-16是编码 转录 调控因子 中叉头家族/ 肝细胞 核心因子3（hnf-3）的成员。

2017年8月23日 · And DAF-16/FOXO, as a key transcription factor, could integrate different signals from these pathways to modulate aging, and longevity via shuttling from cytoplasm to nucleus. Hence, understanding how DAF-16/FOXO functions will be pivotal to illustrate the processes of aging and longevity.

DAF-16 是人 FOXO家族蛋白 在 线虫动物门 （如 秀麗隱桿線蟲）中的 同源 基因 [1]，在线虫的 胰岛素样生长因子1受体 同源基因 daf-2 产生延长寿命的突变后，DAF-16是被激活的主要的 转录因子 [2]。 ^ Ogg, S; Paradis, S; Gottlieb, S; Patterson, GI; Lee, L; Tissenbaum, HA; Ruvkun, G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.. Nature.

DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional changes in many genes involved in aging, development, stress, metabolism, and ...

2020年1月9日 · The transcription factor DAF-16/FOXO mediates a wide variety of aging-preventive responses by driving the expression of stress resistance and longevity promoting genes.

In Caenorhabditis elegans, there is a single FOXO transcription factor homolog, encoded by the gene, daf-16. As a central regulator for multiple signaling pathways, DAF-16 integrates these signals which results in modulation of several biological processes including longevity, development, fat stora …

2019年2月18日，我所董梦秋实验室在《Aging Cell》在线发表题为“ DAF-16 stabilizes the aging transcriptome and is activated in mid-aged Caenorhabditis elegans to cope with internal stress ”的研究论文。...

In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase cascade.

2017年8月22日 · DAF-16/FOXO integrates signals from different pathways to modulate aging and longevity. Insulin-like molecules bind to DAF-2 receptor to lead to the activation of PI3P pathway composed of AGE-1/AAP-1, PDK-1 as well as AKT-1/2, which inhibits DAF-16/FOXO translocation into nucleus by phosphorylation.