DB/DB MICE——自发性Ⅱ型糖尿病小鼠 - 知乎 - 知乎专栏
db/db小鼠 (diabetes mouse)由 C57BL/KsJ 近亲交配株常染色体隐性遗传衍化而来，属Ⅱ型糖尿病模型。 db基因为4号染色体隐性突变基因，能导致肥胖伴糖尿病，纯合子有 高血糖症；其瘦 …
000642 - Strain Details - The Jackson Laboratory
Mice homozygous for the diabetes spontaneous mutation (<em>Lepr<sup>db</sup></em>) manifest morbid obesity, chronic hyperglycemia, pancreatic beta cell atrophy and become …
DBDB小鼠——二型糖尿病小鼠 - 知乎 - 知乎专栏
db/db小鼠是C57BL/Ks小鼠的突变株，血糖可以由11.1mmol/L（200mg/dl）以下的正常水平逐渐升到33.3mol/L（600mg/dl）以上，平均是31.3mmol/L），雌鼠丧失生殖力，寿命较短（8个 …
ob/ob mice and db/db mice - 知乎 - 知乎专栏
2016年8月10日 · Ob/ob mouse 是一种突变小鼠，过量进食，导致非常肥胖。 它是一种2型糖尿病模型。 突变基因ob的证明使我们发现了瘦素，其对食欲的控制很重要。 第一只Ob/ob mouse …
BKS db/db Mice (JAX® Mice Strain) - Charles River Laboratories
db/db mice are used to model phase 1 to 3 of diabetes type II and obesity. Mice that are homozygous for the diabetes spontaneous mutation (Leprdb) demonstrate morbid obesity, …
Db/Db Mouse - an overview | ScienceDirect Topics
Leptin receptor-deficient mice (db/db) are physiologically similar to the ob/ob model since they carry a spontaneous mutation in the db gene encoding the leptin receptor (according to new …
db/db,db/+和db/m小鼠的区别？ - DXY.cn
2020年4月4日 · 所以db/db是纯合老鼠，db/m是一条链是db杂合另一条是dock7突变。 db/+,一条是db杂合，另外一条是wt链。 此外db/m和db/+ 表型是不一样的国内常常混为一谈。 林Lily：你 …
db/db Mice Exhibit Features of Human Type 2 Diabetes That Are …
To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a Western-style diet (WD) to …
[The research applications of db/db mouse] - PubMed
Here we review the history of the discovery of the leptin signaling pathway, the abnormal phenotypes of db/db mice in metabolic, reproductive, immune, etc. Discuss their research …
Characterization of the db/db Mouse Model of Type 2 Diabetes
2018年12月11日 · This chapter presents characterization of the db/db mouse model of type 2 diabetes. The protocol describes generation of the mice along with measurements of physical …