DBCO-acid is a click chemistry reagent used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups [1] [2] [3] [4] .

DBCO-acid 是一种点击化学试剂，可用于合成 ADC linker DBCO-NHS ester (HY-115524 和 HY-115545)，及偶联物 DBCO-PEG-MMAE (HY-111012 和 HY-126690)。 DBCO-acid 含有 DBCO 基团，可以和含有 Azide 基团的分子发生环张力 (strain) 促进的炔-叠氮环加成反应 (SPAAC)。

2024年12月18日 · DBCO-acid的反应原理主要基于其DBCO基团与含有叠氮基团的化合物之间发生的无铜点击化学反应，也称为叠氮-炔烃环加成反应（SPAAC）。 这种反应类型以其高效性和选择性著称，能够在无需催化剂的情况下进行。

DBCO-Acid is a non-activated building block and adds minimal spacer to modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize amine-containing molecules through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only.

11,12-Didehydro-gamma-oxodibenz[b,f]azocine-5(6H)-butanoic acid | C19H15NO3 | CID 91757805 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

DBCO Acid is an amine-reactive non-activated building block used for derivatizing amine-containing molecule in the presence of activators (e.g. EDC, or HATU) through a stable amide bond. Short spacer arm adds minimal mass to modified molecules (305.11 daltons). DBCO reagents are the most commonly used substrates for copper-free click chemistry.

Aldrich-761516; Dibenzocyclooctyne-acid storage temp.: -20C, 95%; Synonyms: DBCO-Acid; Linear Formula: C21H19NO3; Empirical Formula: C21H19NO3; find related products, papers, technical documents, MSDS & more at Sigma-Aldrich.

DBCO (二苯并环辛炔, Dibenzocyclooctyne) 用于无需 铜离子 催化的叠氮-炔环加成 (SPAAC) 反应，该反应的 二级反应 动力学常数可达到 1。 DBCO 系列产品包括可用于进一步连接的 DBCO-acid、DBCO-amine、DBCO-PEG-COOH、DBCO-PEG-amine，以及 DBCO 标记的 Biotin、 荧光染料 和生化小分子等。 DBCO (二苯并环辛炔) 氨基衍生物，可与含有 羧基 的生化小分子形成稳定 酰胺键 连接。

DBCO Acid is a bifunctional building block comprising of an acid terminus useful for reaction with amine containing linkers in presence of activators such as EDC or HATU and a dibenzocyclooctyne (DBCO) terminus useful for copper-free click chemistry.

2024年8月16日 · DBCO-acid（DBCO-COOH，二苯并环辛炔接羧基）是一种结合了DBCO（Dibenzocyclooctyne，二苯并环辛炔）基团和羧基（-COOH）的功能化化合物。 此类化合物可以与小分子PEG Linker连接，用于在生物正交化学和生物分子修饰中的广泛应用。