DBCO-PEG4-alkyne is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

DBCO group can exclusively react with azide-tagged molecules or biomolecules to form a stable triazole. The click chemistry is also known as strain promoted alkyne-azide cycloaddition (SPAAC), DBCO reagent has become widely used in …

2023年2月23日 · DBCO (二苯并环辛炔, Dibenzocyclooctyne) 试剂是用于应变促进的炔叠氮化物环加成（SPAAC）的最具反应性的环炔之一，可实现无铜点击化学。 通常利用多肽中的氨基，巯基或羧基，把DBCO连接到多肽上， DBCO用于无需铜离子催化的叠氮-炔环加成 (SPAAC) 反应，该反应的二级反应动力学常数可达到 1。 DBCO 系列产品包括可用于进一步连接的 DBCO-acid、DBCO-amine、DBCO-PEG-COOH、DBCO-PEG-amine，以及 DBCO 标记的 Biotin、荧光染 …

DBCO-PEG4-alkyne is a heterobifunctional linker containing a DBCO moiety and an alkyne group for sequential click chemistry with two different azides. The dibenzocyclooctyne group (DBCO) is thermally stable with high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst.

2024年6月27日 · DBCO-PEG-Alkyne，全称二苯并环辛炔-聚乙二醇-炔基，是一种独特的异双功能PEG（聚乙二醇）试剂。 这种化合物结合了DBCO（二苯并环辛炔）、PEG和Alkyne（炔基）三种 不同的 化学结构，赋予了其独特的化学和生物特性，使其在生物医学、材料科学和化学合成等领域具有广泛的应用前景。 一、结构特点. DBCO-PEG-Alkyne的结构中，DBCO部分是一个二烯基环氧化合物，它以其高反应活性和选择性著称，可以在无催化剂的条件下与叠氮化物基团进行 高 …

DBCO-PEG4-alkyne | C30H34N2O6 | CID 146026147 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

DBCO (二苯并环辛炔, Dibenzocyclooctyne) 用于无需铜离子催化的叠氮-炔环加成 (SPAAC) 反应，该反应的二级反应动力学常数可达到 1。 DBCO 系列产品包括可用于进一步连接的 DBCO-acid、DBCO-amine、DBCO-PEG-COOH、DBCO-PEG-amine，以及 DBCO 标记的 Biotin、荧光染料和生化小分子等。

DBCO对 叠氮化物 具有非常高的反应选择性，可用于修饰生物分子，包括肽、蛋白质、酶、活细胞、整个生物体等。 在生理温度和 pH值 范围内，DBCO基团不与胺或 羟基 反应，DBCO也与叠氮化物基团发生反应DBCO也被称为ADIBO（=氮杂二苯并环辛炔）或DIBAC（=二苯并氮杂环辛炔）。

DBCO (dibenzocyclooctene) is a cycloalkyne, which can react with azide through 1,3-dipolar cycloaddition promoted by strain in aqueous solution, which is a biorthogonal reaction, also known as copper free click reaction.

DBCO can react with azide-tagged molecules or biomolecules by strain-promoted azide-alkyne cycloaddition (SPAAC) click reaction and the second-order kinetic constant can reach 1. In addition, they can also react with nitrones via strain-promoted alkyne-nitrone cycloaddition (SPANC) click reaction.