DBCO reagent is a class of click chemistry labeling reagents containing a very reactive DBCO ((Dibenzocyclooctyne) group, DBCO reagent can react with azide-tagged molecules or biomolecules via copper-free Click Chemistry.

EZ-Link TFP Ester-PEG4-DBCO is an amine-reactive hetero-bifunctional crosslinker that contains a dibenzylcyclooctyne (DBCO) group for copper-free click-chemistry applications. This crosslinker can be used to label a variety of amine-containing molecules such as proteins, biomolecules, or small molecules.

The EZ-Link DBCO Protein Labeling Kit provides everything needed to covalently label proteins with a dibenzylcyclooctyne (DBCO) group for copper-free click chemistry applications. This kit contains the necessary materials to perform five labeling reactions and subsequent purification for removal of excess DBCO reagent.

Dibenzocyclooctyne-amine (DBCO-NH2), is a heterobifunctional linker containing a DBCO moiety commonly used for the site-specific functionalization of nanobodies, enabling the addition of reactive DBCO groups for subsequent click chemistry reactions.

To get started, simply two reagents are required (DBCO and azide). These crosslinkers are the most efficient and quantitative linkers available and produce high quality, easily reproducible conjugates for better performance in your assays.

DBCO Linkers. The dibenzocyclooctyne group (DBCO) is thermally stable with high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst. The ligation reaction is very fast and results in almost quantitative yield of stable triazoles.

It combines a dibenzocyclooctyne (DBCO) group with a polyethylene glycol (PEG) chain, making it ideal for bioorthogonal click chemistry. This compound enables efficient, catalyst-free reactions for precise biomolecule labeling, drug delivery, and surface modification, while its PEG component enhances solubility and biocompatibility.

This DBCO-Azide method requires to activate the biomolecule #1 with DBCO reagent, and the biomolecule #2 with azide, then to mixing the two activated biomolecules to form a conjugate. Features

DBCO PEG linkers, DBCO reagents is a class of labeling reagents containing a very reactive DBCO ( (Dibenzocyclooctyne) group, DBCO linkers is reactive toward azide without Cu catalyst.

oYo-Link® DBCO enables site-specific labeling to the heavy chain of compatible antibodies with up to two DBCO labels per antibody. oYo-Link® enables the click reaction to take place prior to antibody labeling which results in highly efficient click reactions.