2025年1月1日 · In this review, we provide an overview across studies investigating the effects of NAc DBS in humans and animals and discuss potential mechanisms underlying its clinical efficacy. We address the anatomical properties of NAc and discuss, in particular, the frequently reported differential effects of NAc shell and NAc core DBS.

2023年9月1日 · NAc-DBS holds metabolic modulatory potential for enhancing mitochondrial function in the dopaminergic pathway. To advance the clinical use of NAc-DBS in MDD treatment, comprehensive research into cellular modifications, circuit-based alterations, and behavioral outcomes is essential.

本研究为齿状回中pvi参与nac-dbs的抗抑郁作用提供了证据，nac-dbs 通过vta-dg 投射和ca1-nac投射增加齿状回pvi的活性，进而逆转抑郁小鼠齿状回中神经增殖损伤，从而实现抗抑郁作用。

2024年2月15日 · We found that long-term and repeated, but not single, NAc-DBS induced robust antidepressant responses in CUMS mice. Moreover, even a single trial NAc-DBS led to the elevation of the...

2022年11月1日 · Deep brain stimulation (DBS) of NAc has been identified as an effective treatment for severe refractory major depression; however, the underlying mechanism of NAc-DBS in MDD treatment remains elusive.

2023年1月4日 · Deep brain stimulation (DBS) of the nucleus accumbens (NAc) (NAc-DBS) is an effective solution to refractory obsessive-compulsive disorder (OCD). However, evidence for the neurobiological mechanisms of OCD and the effect of NAc-DBS is still lacking.

2022年9月22日 · The nucleus accumbens (NAc) is a crucial region in the reward circuit and is related to anhedonia, the pivotal symptom of major depression disorder (MDD). Deep brain stimulation (DBS) of NAc has been identified as an effective treatment for severe refractory major depression; however, the underlying …

In this study, using the chronic unpredictable mild stress (CUMS) mouse model, we investigated the behavioral and neurobiological effects of NAc-DBS on the multidimensional depression-like phenotypes induced by CUMS by integrating behavioral, in vivo microdialysis coupled with high-performance liquid chromatography-electrochemical detector ...

2024 年 2 月 15 日，北京基础医学研究所认知与脑科学中心 在 Molecular psychiatry 发表 “NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA”， 揭示了 NAc-DBS 通过去抑制 VTA 中的 DA 神经元来 缓解 CUMS 造模小鼠的抑郁样行 …

2013年10月23日 · We explored the role of Nucleus accumbens (Nac) as a target for treatment. We made a systematic review of all studies examining the mechanisms of action of high frequency brain stimulation and the pathophysiology of MDD. We also reported all the studies exploring the therapeutic potential of DBS in MDD.