2024年3月1日 · In a subgroup of well selected patients, deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) or globus pallidus internus (GPi) can provide relief from motor symptoms as well as complications related to dopaminergic treatments, such as dyskinesia.

2020年5月13日 · Deep brain stimulation (DBS) of the subthalamic nucleus is a symptomatic treatment of Parkinson’s disease but benefits only to a minority of patients due to stringent...

dbs通常用于治疗帕金森病（pd）、 特发性震颤 和肌张力障碍等运动障碍，经过fda和ce批准后成为这些疾病的标准治疗手段。此外，dbs已用于神经性疼痛和集束性头痛等疼痛综合征，以及癫痫等疾病。

增强型黄色荧光蛋白（EYFP）是最早的黄色荧光蛋白突变体，有四个氨基酸发生突变，使得 EYFP的发射光变为黄绿色，且荧光强度与EGFP荧光强度相似。 不过EYFP虽已被广泛应用，但它本身存在一些缺陷导致其并非最理想的荧光蛋白。 目前， mCitrine和mVenus在EYFP基础上改进的黄色荧光变体应用较为广泛。 另外，还有一种经合成的DNA重排获得的 能量转移黄色荧光蛋白YPet，亮度在黄色荧光蛋白中是最强的，且光稳定性较强。 同时，YPet比mVenus或者其他 …

1987年，Benabid教授受DeLong教授关于基底节核团的五种功能神经环路模型的研究启发，尝试给帕金森病（Parkinson′s disease，PD）患者做丘脑腹中间核（ventral intermediate nucleus，Vim）的高频刺激，最终建立起了除左旋多巴之外另一个最重要的PD治疗方法——脑深部电刺激（deep brain stimulation，DBS）[1]。 随后，在1997年7月，美敦力（Medtronic）公司的脑起搏器震颤控制疗法在美国通过FDA批准，用以治疗原发性震颤与PD震颤。

stimulation (DBS) targeting the subthalamic nucleus (STN) or globus pallidus internus (GPi) can provide relief from motor symptoms as well as complications related to dopaminergic treatments, such as dyskinesia. DBS is standard of care for symptomatic treatment, and symptom reduction seems to occur due to neuromodulatory effects.

2014年12月23日 · As expected, the DBS, YFS and YFP communities exhibited more similar metabolic potentials compared with that of FK (Supplementary Figure 2c), mirroring their relatively similar environmental conditions (Supplementary Figure 1a) and community composition .

2019年10月17日 · 近日，一组来自麻省理工学院（MIT）和波士顿大学（Boston University）的研究人员使用基因编码荧光指示探针SomArchon成功实现了对活体小鼠大脑中神经元活动的实时精密显像。 这项发明近日被发表在顶级期刊《Nature》上。 阅读链接： Nature|新型荧光探针技术：可对活体小鼠大脑中神经元活动实时精密显像. 3，模型仅1MB，更轻量的人脸检测模型开源，效果不弱于主流算法. 来源：量子位. AI模型越来越小，需要的算力也也来越弱，但精度依旧有保障。 …

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2017年9月2日 · Deep brain stimulation in thalamic regions has been proposed as a treatment for epilepsy. The electrical current excites thalamocortical activity which is controlled by γ-aminobutyric acid (GABA)ergic interneurons in the reticular thalamic nucleus (nRT).